Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole
Drug ID BADD_D01898
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status approved; investigational
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D08463
MeSH ID D064750
PubChem ID 5029
TTD Drug ID D0KL4J
NDC Product Code 65162-724
UNII 32828355LL
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H21N3O3S
CAS Registry Number 117976-89-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin mass23.07.04.014--Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.0040.000573%
Acute kidney injury20.01.03.0160.000911%
Functional gastrointestinal disorder07.11.01.016--Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000911%Not Available
Lacrimal structural disorder06.06.04.013--Not Available
Hepatic cancer16.07.02.004; 09.04.02.008--Not Available
Hepatocellular carcinoma16.07.02.005; 09.04.02.0100.000391%Not Available
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 23.03.05.005; 10.01.01.0210.000391%Not Available
Candida infection11.03.03.021--
Device related thrombosis24.01.01.027; 08.07.05.0010.000260%Not Available
Abdominal mass07.01.01.003--Not Available
Adenocarcinoma gastric16.13.03.002; 07.21.02.0020.000260%Not Available
Chronic gastritis11.07.01.016; 10.04.04.011; 07.08.02.0050.000391%Not Available
Wernicke's encephalopathy17.13.01.013; 14.12.02.0130.000391%Not Available
Richter's syndrome16.28.02.005; 01.15.02.0050.000260%Not Available
Gastric mucosal lesion07.11.03.0070.000391%Not Available
Gastrointestinal polyp haemorrhage16.05.01.008; 24.07.02.046; 07.20.01.0110.000521%Not Available
End stage renal disease20.01.03.0190.000260%Not Available
Heavy menstrual bleeding21.01.03.005--Not Available
Hypergastrinaemia07.11.03.0140.000260%Not Available
Intermenstrual bleeding21.01.01.015--Not Available
Mucosal disorder08.01.06.029--Not Available
Pharyngeal swelling22.04.05.028--Not Available
Product intolerance08.06.01.045--Not Available
Taste disorder07.14.03.004; 17.02.07.029--Not Available
Therapeutic response changed08.06.01.059--Not Available
Therapy non-responder08.06.01.063--Not Available
Treatment noncompliance12.09.02.006; 08.06.01.0670.000573%Not Available
Vulvovaginal inflammation21.14.02.014--Not Available
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