Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rabeprazole
Drug ID BADD_D01898
Description Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status approved; investigational
ATC Code A02BC04
DrugBank ID DB01129
KEGG ID D08463
MeSH ID D064750
PubChem ID 5029
TTD Drug ID D0KL4J
NDC Product Code 65162-724
UNII 32828355LL
Synonyms Rabeprazole | 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole | Dexrabeprazole | E 3810 | E3810 | Pariet | Rabeprazole Sodium | Sodium, Rabeprazole | 1H-Benzimidazole, 2-(((4-(3-methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-, Sodium Salt | Aciphex | LY-307640 | LY 307640 | LY307640
Chemical Information
Molecular Formula C18H21N3O3S
CAS Registry Number 117976-89-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Autoimmune hepatitis10.04.09.001; 09.01.07.019--Not Available
Back pain15.03.04.005--
Benign neoplasm of skin16.26.01.006; 23.10.01.006--Not Available
Bladder pain20.02.02.001--Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blood creatine phosphokinase increased13.04.01.001--
Body temperature increased13.15.01.001--Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.002--Not Available
Breast enlargement21.05.04.001--Not Available
Breast neoplasm16.10.02.001; 21.05.01.004--Not Available
Breast pain21.05.05.003--
Bronchitis22.07.01.001; 11.01.09.001--
Bundle branch block02.03.01.009--Not Available
Bursitis12.04.03.010; 15.04.01.001--Not Available
Capillary fragility increased13.01.02.022--Not Available
Cardiac arrest02.03.04.0010.000260%
Cardiovascular disorder02.11.01.010; 24.03.02.009--Not Available
Cataract06.06.01.001--
Cellulitis23.11.02.004; 11.02.01.001--Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.000573%Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.0110.000781%Not Available
Chills08.01.09.001; 15.05.03.016--
Choking sensation22.12.03.004; 19.01.02.002--Not Available
Cholangitis09.02.01.002--Not Available
Cholecystitis09.03.01.001--
Cholelithiasis09.03.01.0020.000260%Not Available
Clostridium difficile colitis07.19.01.004; 11.02.02.004--Not Available
Colitis07.08.01.001--
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