Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Raltegravir
Drug ID BADD_D01905
Description Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval.
Indications and Usage For the treatment of HIV-1 infection in conjunction with other antiretrovirals.
Marketing Status approved
ATC Code J05AJ01
DrugBank ID DB06817
KEGG ID D06676
MeSH ID D000068898
PubChem ID 54671008
TTD Drug ID D0I1FQ
NDC Product Code 0006-0477; 0006-3603; 50090-1085; 65977-0049; 82982-055; 17381-749; 0006-0227; 53002-1686; 71205-777; 68071-2113; 0006-3080; 0006-0473
UNII 22VKV8053U
Synonyms Raltegravir Potassium | Potassium, Raltegravir | Raltegravir | MK 0518 | 0518, MK | MK0518 | MK-0518 | Isentress
Chemical Information
Molecular Formula C20H21FN6O5
CAS Registry Number 518048-05-0
SMILES CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)O)C(=O)NCC3=CC=C(C=C3)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Fatigue08.01.01.002--
Flatulence07.01.04.0020.004120%
Gastric ulcer07.04.03.0020.001648%
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.0030.003626%
Gastrointestinal disorder07.11.01.0010.006098%Not Available
Genital herpes21.10.03.008; 11.05.02.012--Not Available
Headache17.14.01.001--
Hepatic cirrhosis09.01.04.0010.002472%Not Available
Hepatic failure09.01.03.0020.002472%
Hepatic function abnormal09.01.02.0010.001648%Not Available
Hepatitis09.01.07.0040.001648%Not Available
Hepatocellular injury09.01.07.0080.009889%Not Available
Hepatomegaly09.01.05.0010.004120%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.010713%Not Available
Herpes zoster17.09.03.026; 23.11.05.005; 11.05.02.003--
Hypercoagulation01.01.02.0070.001648%Not Available
Hyperkalaemia14.05.03.0010.006428%
Hypersensitivity10.01.03.003--
Hypersplenism01.09.02.0020.001648%Not Available
Hypoglycaemia14.06.03.001; 05.06.03.0010.001648%
Immune system disorder10.02.01.0010.001648%Not Available
Insomnia19.02.01.002; 17.15.03.0020.017635%
Intestinal obstruction07.13.01.0020.002472%Not Available
Kaposi's sarcoma16.33.02.001; 11.05.17.0010.001648%Not Available
Lipoma15.09.01.001; 16.18.01.0010.004450%Not Available
Liver disorder09.01.08.0010.001648%Not Available
Lung disorder22.02.07.0010.002472%Not Available
Lymph node pain01.09.01.0070.003626%
Lymphadenopathy01.09.01.0020.002472%Not Available
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene