| Drug Name |
Ranolazine |
| Drug ID |
BADD_D01915 |
| Description |
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.[A189234] Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.[L3580] With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.[L5440] |
| Indications and Usage |
Ranolazine is indicated for the treatment of chronic angina. It can be used alone or in conjunction with nitrates, beta-blockers, angiotensin receptor blockers, anti-platelet drugs, calcium channel blockers, lipid-lowering drugs, and ACE inhibitors.[L3580]
Ranolazine has also been used off-label for the treatment of certain arrhythmias, including ventricular tachycardia, however, this use is not strongly supported by scientific evidence.[A174940] Ranolazine has also been studied for the treatment of acute coronary syndrome, microvascular coronary dysfunction, arrhythmia, and glycemic control, which are not yet approved indications.[A174898,L3580] |
| Marketing Status |
approved; investigational |
| ATC Code |
C01EB18 |
| DrugBank ID |
DB00243
|
| KEGG ID |
D05700
|
| MeSH ID |
D000069458
|
| PubChem ID |
56959
|
| TTD Drug ID |
D03HYQ
|
| NDC Product Code |
50370-0019; 61958-1004; 69367-294; 70625-207; 71610-518; 59651-009; 64552-4024; 67651-0224; 68180-355; 70756-703; 15308-0718; 29300-296; 29300-297; 50228-424; 68180-354; 69367-293; 70771-1500; 63304-017; 68462-319; 69097-221; 72319-021; 40006-043; 42765-048; 73680-0012; 27241-126; 42385-964; 50268-722; 50268-723; 59651-010; 63304-018; 65162-379; 67877-525; 69097-222; 72578-065; 53747-042; 65862-981; 27241-125; 66039-943; 67835-0011; 42571-324; 61958-1003; 63552-142; 72640-001; 31722-668; 31722-669; 43353-880; 47335-624; 68462-320; 70771-1499; 71205-867; 72319-022; 47621-304; 51604-1154; 62512-0076; 67651-0258; 42291-774; 42385-963; 42571-325; 47335-625; 65162-376; 71205-868; 72578-064; 48087-0082; 63552-143; 42291-773; 50228-423; 60687-549; 67877-526; 70625-206; 70756-704; 11014-0108; 48087-0106; 49711-1518; 64220-213; 65372-1190; 70966-0008; 45963-418; 45963-419 |
| UNII |
A6IEZ5M406
|
| Synonyms |
Ranolazine | N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide | Renolazine | Ranolazine Hydrochloride | Hydrochloride, Ranolazine | Ranolazine Dihydrochloride | Dihydrochloride, Ranolazine | Ranolazine HCl | HCl, Ranolazine | Ranexa | RS 43285-193 | RS 43285 193 | RS 43285193 | RS 43285 | 43285, RS | RS-43285 | RS43285 |
