Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Rifabutin
Drug ID BADD_D01935
Description A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
Indications and Usage For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.
Marketing Status approved; investigational
ATC Code J04AB04
DrugBank ID DB00615
KEGG ID D00424
MeSH ID D017828
PubChem ID 135398743
TTD Drug ID D05CHI
NDC Product Code 70518-3731; 73309-108; 68180-285; 10135-738; 0013-5301; 59762-1350; 70954-041
UNII 1W306TDA6S
Synonyms Rifabutin | Rifabutine | Ansamycin | Mycobutin | Ansatipine | LM-427 | LM 427 | LM427 | Alfacid | Ansatipin
Chemical Information
Molecular Formula C46H62N4O11
CAS Registry Number 72559-06-9
SMILES CC1C=CC=C(C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)OC(C6=O)(OC= CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute hepatic failure09.01.03.0010.021874%Not Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.04.005--
Anaemia01.03.02.001--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Aphasia19.21.01.001; 17.02.03.001--
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.0010.032082%Not Available
Bacteraemia11.01.11.001--
Blood bilirubin increased13.03.04.018--
Body temperature increased13.15.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Burkitt's lymphoma16.28.04.001; 01.15.04.001--Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.009--Not Available
Chest pain02.02.02.011; 22.12.02.003; 08.01.08.002--Not Available
Chromaturia20.02.01.002--
Chronic obstructive pulmonary disease22.03.01.0070.014583%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.004--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Congenital anomaly03.02.01.001--Not Available
Conjunctivitis06.04.01.002; 11.01.06.012--
Corneal deposits06.06.03.0020.014583%Not Available
Cough22.02.03.0010.014583%
Dermatitis23.03.04.002--Not Available
Developmental delay19.07.05.003; 08.01.03.037--Not Available
Diarrhoea07.02.01.001--
Drug hypersensitivity10.01.01.0010.131245%Not Available
Drug ineffective08.06.01.0060.088955%Not Available
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