Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rifabutin
Drug ID BADD_D01935
Description A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.
Indications and Usage For the prevention of disseminated Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection.
Marketing Status approved; investigational
ATC Code J04AB04
DrugBank ID DB00615
KEGG ID D00424
MeSH ID D017828
PubChem ID 135398743
TTD Drug ID D05CHI
NDC Product Code 70518-3731; 73309-108; 68180-285; 10135-738; 0013-5301; 59762-1350; 70954-041
UNII 1W306TDA6S
Synonyms Rifabutin | Rifabutine | Ansamycin | Mycobutin | Ansatipine | LM-427 | LM 427 | LM427 | Alfacid | Ansatipin
Chemical Information
Molecular Formula C46H62N4O11
CAS Registry Number 72559-06-9
SMILES CC1C=CC=C(C(=O)N=C2C(=C3C(=C4C2=NC5(N4)CCN(CC5)CC(C)C)C6=C(C(=C3O)C)OC(C6=O)(OC= CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug interaction08.06.03.0010.014583%Not Available
Dysgeusia17.02.07.003; 07.14.03.0010.049581%
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.064164%
Dyspnoea02.11.05.003; 22.02.01.004--
Eosinophilia01.02.04.001--
Eructation07.01.02.003--
Eye disorder06.08.03.001--Not Available
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Granulocytopenia01.02.03.003--Not Available
Haemolysis01.06.04.002--
Headache17.14.01.0010.032082%
Hepatic failure09.01.03.0020.014583%
Hepatitis09.01.07.004--Not Available
Hepatitis toxic09.01.07.017; 12.03.01.0160.014583%Not Available
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Hypoxia22.02.02.0030.014583%
Immune system disorder10.02.01.001--Not Available
Influenza like illness08.01.03.010--
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukopenia01.02.02.0010.051040%Not Available
Lymphopenia01.02.02.002--Not Available
Malaise08.01.01.0030.032082%
Myalgia15.05.02.001--
Myositis15.05.01.001--
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