Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Salmeterol
Drug ID BADD_D01981
Description Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol].[A190459] Salmeterol was first described in the literature in 1988.[A190477] Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.[A183737] Salmeterol was granted FDA approval on 4 February 1994.[L11542]
Indications and Usage Salmeterol is indicated in the treatment of asthma with an inhaled corticosteroid, prevention of exercise induced bronchospasm, and the maintenance of airflow obstruction and prevention of exacerbations of chronic obstructive pulmonary disease.[L11545,L11548,L11551,L11554,L11557]
Marketing Status approved
ATC Code R03AC12
DrugBank ID DB00938
KEGG ID D05792
MeSH ID D000068299
PubChem ID 5152
TTD Drug ID D0L5YV
NDC Product Code 63850-3912
UNII 2I4BC502BT
Synonyms Salmeterol Xinafoate | Xinafoate, Salmeterol | Salmeterol | Serevent
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 89365-50-4
SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pharyngitis11.01.13.003; 07.05.07.004; 22.07.03.004--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pulmonary congestion24.03.08.001; 22.01.03.002; 02.05.02.002--Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.003263%Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.0040.003263%
Respiratory disorder22.02.07.002--Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.003263%
Rhinitis22.07.03.006; 11.01.13.004--
Rhinitis allergic22.04.04.003; 10.01.04.003--
Rhinorrhoea22.12.03.021--
Sinus congestion22.04.06.001--Not Available
Sinus headache17.14.01.002; 22.12.03.022--
Sinusitis22.07.03.007; 11.01.13.005--
Sleep disorder19.02.04.001--Not Available
Sneezing22.12.03.024--
Stridor22.04.02.003--
Supraventricular tachycardia02.03.03.012--
Swelling08.01.03.015--Not Available
Tachycardia02.03.02.0070.003263%Not Available
Tenderness08.01.08.005--Not Available
Tension19.06.02.005--Not Available
Throat irritation22.12.03.029; 07.05.05.037--Not Available
Toothache07.09.06.001--
Tracheitis22.07.03.009; 11.01.13.007--
Tracheobronchitis22.07.01.016; 11.01.09.020--Not Available
Tremor17.01.06.0020.004894%
Type I hypersensitivity10.01.03.006--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
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ADReCS-Target
Drug Name ADR Term Target
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