Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Salmeterol
Drug ID BADD_D01981
Description Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol].[A190459] Salmeterol was first described in the literature in 1988.[A190477] Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.[A183737] Salmeterol was granted FDA approval on 4 February 1994.[L11542]
Indications and Usage Salmeterol is indicated in the treatment of asthma with an inhaled corticosteroid, prevention of exercise induced bronchospasm, and the maintenance of airflow obstruction and prevention of exacerbations of chronic obstructive pulmonary disease.[L11545,L11548,L11551,L11554,L11557]
Marketing Status approved
ATC Code R03AC12
DrugBank ID DB00938
KEGG ID D05792
MeSH ID D000068299
PubChem ID 5152
TTD Drug ID D0L5YV
NDC Product Code 63850-3912
UNII 2I4BC502BT
Synonyms Salmeterol Xinafoate | Xinafoate, Salmeterol | Salmeterol | Serevent
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 89365-50-4
SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria10.01.06.001; 23.04.02.001--
Varicella23.11.05.008; 11.05.02.004--Not Available
Ventricular tachycardia02.03.04.010--
Viral infection11.05.04.001--Not Available
Vomiting07.01.07.003--
Viral diarrhoea11.05.04.012; 07.19.02.008--Not Available
Respiratory tract congestion22.02.07.003--Not Available
Musculoskeletal stiffness15.03.05.027--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Dental discomfort07.09.06.002--Not Available
Major depression19.15.01.0030.003263%Not Available
Vasodilation procedure25.03.01.001--Not Available
Adverse event08.06.01.0100.010441%Not Available
Cardiac disorder02.11.01.003--Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Inflammation08.01.05.007; 10.02.01.089--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Ill-defined disorder08.01.03.049--Not Available
Respiratory tract infection22.07.07.001; 11.01.08.017--Not Available
Oropharyngeal discomfort07.05.05.008; 22.12.03.015--Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.004--
Acute kidney injury20.01.03.0160.003263%
Rheumatic disorder15.03.04.018; 10.02.01.048--Not Available
Candida infection11.03.03.021--
Asthmatic crisis22.03.01.018--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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