Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle atrophy17.05.03.004; 15.05.03.0030.000045%Not Available
Muscle contractions involuntary15.05.03.008; 17.05.03.0010.000082%Not Available
Muscle rigidity17.05.02.005; 15.05.04.0010.000297%Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.0050.000368%Not Available
Muscular weakness17.05.03.005; 15.05.06.0010.000289%
Mutism17.02.08.007; 19.19.01.0010.000045%Not Available
Myalgia15.05.02.001--
Mydriasis17.02.11.003; 06.05.03.0040.000577%Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Myoclonus17.02.05.0080.000461%Not Available
Myoglobinuria15.05.03.009; 02.04.02.006; 20.02.01.0100.000019%Not Available
Myopathy15.05.05.0010.000051%Not Available
Myositis15.05.01.0010.000070%
Nasal congestion22.04.04.001--
Nasal dryness22.04.03.0020.000050%Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
Negativism19.05.01.0120.000028%Not Available
Neonatal disorder18.04.01.0010.000013%Not Available
Neoplasm16.16.02.001--Not Available
Nephrocalcinosis20.04.01.0010.000038%Not Available
Nerve compression17.09.02.002; 12.01.12.0010.000013%Not Available
Nervous system disorder17.02.10.0010.000155%Not Available
Nervousness19.06.02.0030.000306%Not Available
Neurogenic bladder20.03.03.001; 17.10.01.0020.000019%Not Available
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.0050.000070%Not Available
Night sweats23.02.03.006; 08.01.03.0310.000414%Not Available
Nightmare19.02.03.0030.000381%Not Available
Nipple pain21.05.05.0090.000025%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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