Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute generalised exanthematous pustulosis11.07.01.018; 10.01.01.034; 23.03.10.002; 12.03.01.0050.000092%Not Available
Deafness unilateral04.02.01.0110.000013%Not Available
Underweight14.03.02.0170.000060%Not Available
Hypoacusis04.02.01.0060.000149%
Performance status decreased08.01.03.0420.000051%Not Available
Localised oedema08.01.07.011; 02.05.04.006; 14.05.06.0090.000013%
Brain oedema17.07.02.003; 12.01.10.0100.000064%
Chapped lips07.05.01.0040.000019%Not Available
Emotional distress19.04.02.008--Not Available
Psychomotor skills impaired17.02.10.005; 19.22.01.0020.000045%Not Available
Lip blister23.03.01.016; 07.05.01.0070.000034%Not Available
Sudden cardiac death08.04.01.008; 02.03.04.0160.000025%Not Available
General physical health deterioration08.01.03.0180.000362%Not Available
Anal haemorrhage24.07.02.029; 07.12.03.0040.000013%
Muscle fatigue15.05.03.0060.000019%Not Available
Homicidal ideation19.05.01.0080.000127%Not Available
Urethral haemorrhage24.07.03.006; 20.07.01.0030.000013%Not Available
Left ventricular hypertrophy02.04.02.0140.000051%Not Available
Muscle tightness15.05.03.0070.000136%Not Available
Anal sphincter atony17.05.02.009; 07.03.01.0030.000025%Not Available
Balance disorder08.01.03.081; 17.02.02.0070.000313%Not Available
Impatience19.05.01.0140.000032%Not Available
Idiosyncratic drug reaction08.06.01.0020.000013%Not Available
Bradyphrenia19.10.03.002; 17.03.03.0040.000153%Not Available
Lung cancer metastatic22.08.01.004; 16.19.02.0030.000019%Not Available
Neonatal hypoxia22.11.02.002; 18.04.15.0020.000032%Not Available
Pneumomediastinum22.09.03.0040.000025%Not Available
Dysstasia15.03.05.011; 08.01.03.089; 17.02.02.0120.000070%Not Available
Intervertebral disc protrusion15.10.01.0040.000038%Not Available
Hyposmia22.04.03.008; 17.04.04.0030.000032%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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