Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Right ventricular hypertrophy02.04.02.0340.000051%Not Available
Meconium in amniotic fluid18.05.01.0070.000025%Not Available
Semen discolouration21.03.03.0080.000057%Not Available
Eosinophilic pneumonia chronic01.02.04.017; 22.01.01.0200.000045%Not Available
Non-alcoholic steatohepatitis14.08.04.024; 09.01.07.0350.000013%Not Available
Foetal macrosomia18.03.01.0030.000013%Not Available
Retroplacental haematoma24.07.03.029; 18.02.01.0060.000013%Not Available
Bradycardia neonatal18.04.07.004; 02.03.02.0190.000102%Not Available
Biliary dyskinesia09.03.02.0040.000013%Not Available
Lymphomatoid papulosis23.03.08.0110.000028%Not Available
Cell death14.11.02.005; 08.03.03.0030.000019%Not Available
Eosinophilic colitis07.08.01.019; 01.02.04.0150.000019%Not Available
Aortic dilatation24.03.04.0070.000019%Not Available
Hypertensive emergency24.08.01.0040.000013%Not Available
Poor sucking reflex18.04.04.011; 17.02.01.0080.000013%Not Available
Negative thoughts19.15.02.0120.000060%Not Available
Sopor17.02.04.021; 19.02.04.0020.000528%Not Available
Psychogenic seizure17.12.03.042; 19.24.01.0070.000045%Not Available
Neonatal aspiration22.11.01.008; 18.04.09.0070.000019%Not Available
Ulnar nerve palsy17.09.02.0170.000013%Not Available
Pharyngeal hypoaesthesia22.04.05.017; 17.02.06.0340.000013%Not Available
Diffuse alveolar damage22.01.01.0190.000019%Not Available
Disturbance in social behaviour19.05.01.0180.000019%Not Available
Foot deformity15.10.03.0050.000045%Not Available
Tricuspid valve disease02.07.05.0040.000025%
Cerebral cyst17.18.05.002; 16.09.05.0020.000013%Not Available
Aortic valve disease02.07.03.0020.000019%
Pyelocaliectasis20.01.06.0110.000013%Not Available
Erosive duodenitis07.04.02.0060.000013%Not Available
Accidental death12.01.08.040; 08.04.01.0130.000019%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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