Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
High-pitched crying17.02.05.070; 12.02.11.006; 08.01.03.0900.000047%Not Available
Hypersensitivity pneumonitis22.01.01.027; 10.01.03.0560.000025%Not Available
Idiopathic intracranial hypertension17.07.02.0110.000045%Not Available
Immune thrombocytopenia10.02.01.083; 01.08.01.0130.000032%Not Available
Infant irritability18.04.04.018; 17.02.05.0720.000019%Not Available
Inhibitory drug interaction08.06.03.0140.000019%Not Available
Intermenstrual bleeding21.01.01.0150.000125%Not Available
Intracranial meningioma malignant17.20.05.001; 16.30.05.0010.000025%Not Available
Jaw clicking15.01.02.0110.000019%Not Available
Juvenile myoclonic epilepsy17.12.03.0370.000038%Not Available
Lactation insufficiency21.05.02.006; 18.06.02.0060.000062%Not Available
May-Thurner syndrome24.04.03.0270.000032%Not Available
Mesenteric panniculitis10.01.03.061; 07.08.03.0250.000019%Not Available
Morning sickness18.02.02.022; 07.01.07.0180.000043%Not Available
Neonatal respiratory distress22.11.02.015; 18.04.10.0040.000083%Not Available
Neonatal seizure18.04.04.019; 17.12.03.0380.000032%Not Available
Obstructive pancreatitis09.02.02.006; 07.18.01.0130.000019%Not Available
Perinatal depression19.15.01.011; 18.06.03.0030.000013%Not Available
Persistent genital arousal disorder21.03.02.027; 17.02.07.0270.000057%Not Available
Pharyngeal swelling22.04.05.0280.000051%Not Available
Psychotic symptom19.03.01.0120.000025%Not Available
Reaction to excipient10.01.01.0420.000053%Not Available
Sensory processing disorder19.22.02.005; 17.02.03.0250.000013%Not Available
Sexually inappropriate behaviour19.05.01.0260.000045%Not Available
Skin indentation23.03.03.0980.000025%Not Available
Splenic cyst16.21.05.001; 01.13.05.0010.000013%Not Available
Subchorionic haematoma24.07.03.037; 18.02.01.0080.000025%Not Available
Substance use disorder19.07.06.0200.000019%Not Available
Superficial vein thrombosis24.01.02.0160.000041%Not Available
Suspected suicide19.12.01.009; 08.04.01.0170.000019%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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