Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug withdrawal syndrome neonatal19.07.06.014; 18.04.13.001; 08.06.02.0080.000287%Not Available
Dry mouth07.06.01.0020.000520%
Dry skin23.03.03.001--
Dry throat22.12.03.005; 07.06.01.0050.000013%Not Available
Duodenal ulcer perforation07.04.02.0030.000057%Not Available
Duodenitis07.08.03.0010.000053%Not Available
Dysaesthesia17.02.06.003; 23.03.03.0770.000076%
Dysarthria17.02.08.001; 19.19.03.0010.000397%
Dyskinesia17.01.02.0060.000641%
Dyslexia19.21.01.003; 17.02.03.0090.000013%Not Available
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.0010.000262%
Dysphagia07.01.06.003--
Dysphonia22.12.03.006; 19.19.03.002; 17.02.08.004--
Dyspnoea22.02.01.004; 02.11.05.003--
Dystonia17.01.03.0010.000302%Not Available
Dysuria20.02.02.0020.000232%
Ear pain04.03.01.0030.000045%
Ear swelling04.03.01.0140.000038%Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.0010.000057%Not Available
Ectopic pregnancy18.02.02.0020.000032%Not Available
Eczema23.03.04.006--
Ejaculation delayed21.03.01.0010.000053%Not Available
Ejaculation disorder21.03.01.0020.000019%
Ejaculation failure21.03.01.0030.000038%Not Available
Electrocardiogram QT prolonged13.14.05.004--
Emotional disorder19.04.02.0050.000113%Not Available
Emotional poverty19.04.02.0150.000127%Not Available
Endometriosis21.07.01.0040.000013%Not Available
Enlarged clitoris05.05.01.004; 21.08.02.0010.000032%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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