| Pharmaceutical Information |
| Drug Name |
Silodosin |
| Drug ID |
BADD_D02020 |
| Description |
Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α1A subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α1A subtype accounts for approximately 75% of α1-adrenoceptors in the prostate.[A231159]
Silodosin was first approved by the FDA in October 2008 [A231159] and it is also approved in Europe and Canada. Silodosin is available as oral capsules with common trade names Rapaflo and Urorec. It is indicated for the symptomatic treatment of benign prostatic hyperplasia in adults.[L32368] Most commonly affecting males over the age of 40 years, benign prostatic hyperplasia is the non-malignant enlargement of the prostate gland, associated with lower urinary tract symptoms that have a negative impact on the quality of life of patients.[A231159] Silodosin works by binding to α1A-adrenoceptors with high affinity and relaxing the lower urinary tract, thereby improving urinary symptoms and alleviating bladder outlet obstruction.[A231229] |
| Indications and Usage |
Silodosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). It is not indicated for the treatment of hypertension.[L32368] |
| Marketing Status |
approved |
| ATC Code |
G04CA04 |
| DrugBank ID |
DB06207
|
| KEGG ID |
D01965
|
| MeSH ID |
C095285
|
| PubChem ID |
5312125
|
| TTD Drug ID |
D0U0VU
|
| NDC Product Code |
42291-777; 83137-0011; 0023-6147; 69238-1421; 42291-778; 27241-144; 27241-145; 31722-635; 60219-1420; 60219-1421; 69539-053; 72789-090; 52544-151; 68180-741; 0023-6142; 59651-096; 62332-405; 69238-1420; 69539-052; 0781-2624; 52544-152; 59651-100; 73005-0002; 33342-385; 62332-406; 42334-001; 65977-0091; 33342-384; 46708-406; 68180-740; 72205-009; 72205-010; 14501-0074; 42765-005; 46708-405; 0781-2623; 31722-636; 59651-095 |
| UNII |
CUZ39LUY82
|
| Synonyms |
silodosin | 1-(3-hydroxypropyl)-5-(2-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethylamino)propyl)indoline-7-carboxamide | KMD 3213 | KMD-3213 | rapaflo |
|
| Chemical Information |
| Molecular Formula |
C25H32F3N3O4 |
| CAS Registry Number |
160970-54-7 |
| SMILES |
CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F |
| Chemical Structure |
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| ADRs Induced by Drug |
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