Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sodium fluoride
Drug ID BADD_D02039
Description Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as [Fluoride ion F-18].[L4894] Sodium fluoride's benefits on dental health were first observed in the 1930s, when individuals in communities with fluoridated drinking water showed less tooth decay than those without fluoridated water. The use of fluoride in dental practice began in the 1940s. Now, sodium fluoride may be found in a variety of gels, varnishes, rinses, toothpaste products, and fluoride treatments provided in dental care.[A181670,A181688] According to the American Dental Association (ADA), thorough evidence reviews have indicated that the use of fluoride to prevent and control dental caries is safe when used correctly and is highly effective in reducing the prevalence of caries.[L7691]
Indications and Usage Sodium fluoride in the oral or topical form is indicated for the prevention and control of dental caries and for the maintenance of dental health.[A181652,L7670] Fluoride supplements in the form of tablets and other formulas may be prescribed to prevent tooth decay in high-risk children aged 6 months to 16 years old whose drinking water source contains low fluoride concentrations.[L7691]
Marketing Status approved
ATC Code A01AA01; A12CD01
DrugBank ID DB09325
KEGG ID D00943
MeSH ID D012969
PubChem ID 5235
TTD Drug ID D02IUD
NDC Product Code 72805-130; 0699-0152; 74724-0020; 75065-001; 75065-004; 75065-007; 79903-033; 0869-0163; 0869-0482; 49452-6740; 10056-530; 10237-786; 11527-044; 11527-045; 11527-750; 11822-4004; 11822-9718; 24794-107; 24794-108; 25047-764; 25047-765; 25047-771; 25047-773; 25047-775; 30142-482; 35000-190; 35000-198; 35000-743; 35000-930; 35000-969; 35000-988; 35000-993; 35000-996; 36800-482; 37000-171; 37000-208; 37000-212; 37000-214; 37000-839; 37000-853; 37000-924; 37000-952; 37000-962; 37012-163; 0126-0286; 37808-576; 0135-0234; 41163-004; 41167-0922; 41167-0953; 41250-004; 41250-576; 42756-1115; 43136-802; 43136-902; 43498-103; 43498-104; 43498-105; 48878-3130; 53045-204; 53045-252; 53045-266; 53942-004; 53942-213; 0273-0370; 58578-0749; 61041-212; 61578-217; 62007-052; 62007-802; 62007-805; 62007-810; 63629-1133; 64778-0216; 64854-018; 64980-307; 65517-2018; 65954-064; 66467-2230; 66467-2240; 67933-0016; 68400-120; 68400-701; 68400-704; 68987-011; 69301-031; 69423-751; 69423-770; 69423-773; 69423-887; 69423-894; 69423-910; 69423-913; 69423-933; 69423-947; 69484-050; 69509-052; 69509-054; 69842-429; 69968-0497; 69968-0690; 70108-005; 70737-016; 72288-004; 72299-011; 72299-016; 72299-020; 75065-021; 77573-012; 14639-6441; 10056-415; 10237-633; 10237-635; 10237-653; 10237-666; 30142-563; 35000-205; 35000-229; 35000-261; 35000-734; 35000-744; 35000-900; 35000-937; 35000-953; 35000-972; 35573-435; 37000-025; 37000-028; 37000-494; 37000-862; 37000-932; 37000-956; 37000-961; 37000-993; 37012-482; 0126-0289; 37808-435; 41163-213; 0135-0558; 41167-0940; 41250-213; 43498-102; 48878-3150; 51009-149; 51009-840; 51009-915; 51824-046; 53045-200; 53045-203; 53045-268; 55316-213; 55882-6118; 55882-6210; 0273-0241; 0273-0393; 57660-003; 61649-731; 62007-053; 62007-055; 62007-100; 62007-126; 62007-316; 62007-820; 62007-825; 62007-826; 0363-0482; 63783-501; 63940-163; 64778-0446; 66467-2270; 67239-0226; 67777-175; 68400-135; 69301-025; 69301-032; 69367-309; 69423-792; 69423-882; 69423-907; 69423-949; 69423-961; 69509-055; 69509-058; 69842-548; 69968-0697; 70605-039; 70766-007; 71141-174; 72288-439; 72288-576; 72299-017; 72551-251; 72655-300; 74690-008; 77935-303; 79481-0201; 81740-002; 82149-001; 82500-010; 83367-102; 86157-0006; 86157-0012; 10237-652; 10237-675; 10237-785; 10237-794; 10237-795; 11822-5927; 24794-105; 35000-127; 35000-195; 35000-199; 35000-233; 35000-264; 35000-418; 35000-742; 35000-902; 35000-924; 37000-022; 37000-167; 37000-469; 37000-511; 37000-925; 37000-943; 37000-958; 37000-968; 37012-004; 0126-0033; 37808-320; 37808-808; 41163-581; 41167-0965; 41250-531; 42291-741; 43136-602; 43136-820; 43136-903; 50268-733; 50594-971; 51206-310; 53045-206; 53045-207; 55301-163; 55315-163; 55873-002; 0273-0345; 0273-0358; 58578-1234; 58657-160; 59883-718; 59883-821; 61041-211; 61995-0601; 62007-307; 62007-829; 63783-400; 65222-411; 65954-041; 0404-1701; 0404-1721; 66923-007; 68400-121; 69367-310; 69367-311; 69423-769; 69423-850; 69423-881; 69423-889; 69423-924; 69423-928; 69509-053; 69509-059; 69745-014; 69842-581; 69968-0537; 69968-0606; 70683-0703; 72135-005; 72299-010; 72299-023; 72476-482; 72551-246; 53942-435; 53942-581; 54473-300; 55316-435; 55882-6116; 56062-163; 0273-0341; 0273-0346; 58578-0517; 58578-0759; 58657-162; 58933-470; 58933-879; 59088-106; 59779-163; 59779-482; 59883-820; 0363-0014
UNII 8ZYQ1474W7
Synonyms Sodium Fluoride | Fluoride, Sodium | Fluorides, Sodium | Sodium Fluorides | Zymafluor | Zymafluors | Fluoristat | Fluoristats | Ossin | Ossins
Chemical Information
Molecular Formula NaF
CAS Registry Number 7681-49-4
SMILES [F-].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Asthenia08.01.01.001--Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Dental caries07.09.01.001--
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Diarrhoea07.02.01.001--
Disturbance in attention19.21.02.002; 17.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Ear disorder04.03.01.001--Not Available
Eczema23.03.04.006--
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.002--
Facial paralysis17.04.03.008--Not Available
Fatigue08.01.01.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Intentional self-injury19.12.01.002; 12.01.08.036--Not Available
Irritability19.04.02.013; 08.01.03.011--
Lip pain07.05.05.029--
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Mouth ulceration07.05.06.004--Not Available
Neoplasm malignant16.16.01.001--Not Available
Oral pain07.05.05.034--
Pain08.01.08.004--
Pain in jaw15.02.01.003--Not Available
Pruritus23.03.12.001--
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
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