| Pharmaceutical Information |
| Drug Name |
Streptomycin sulfate |
| Drug ID |
BADD_D02072 |
| Description |
Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activity.[A233325,A232294] Although streptomycin was the first antibiotic determined to be effective against mycobacterium tuberculosis, it has fallen out of favor due to resistance and is now primarily used as adjunctive treatment in cases of multi-drug resistant tuberculosis.[A233325] |
| Indications and Usage |
Although streptomycin was the first antibiotic available for the treatment of mycobacterium tuberculosis, it is now largely a second line option due to resistance and toxicity.[A233320] Streptomycin may also be used to treat a variety of other infections caused by susceptible strains of aerobic bacteria where other less toxic agents are ineffective. Examples include: _Yersinia pestis_, _Francisella tularensis_, _Brucella_, _Calymmatobacterium granulomatis_ (donovanosis, granuloma inguinale), _H. ducreyi_ (chancroid), _H. influenzae_ (in respiratory, endocardial, and meningeal infections - concomitantly with another antibacterial agents). _K. pneumoniae_ pneumonia (concomitantly with another antibacterial agent), _E.coli_, _Proteus_, _A.aerogenes_, _K. pneumoniae_, and
_Enterococcus faecalis_ in urinary tract infections, _Streptococcus viridans_, _Enterococcus faecalis_ (in endocardial infections - concomitantly with penicillin), and Gram-negative bacillary bacteremia (concomitantly with another antibacterial agent). |
| Marketing Status |
approved; vet_approved |
| ATC Code |
J01GA01; A07AA04 |
| DrugBank ID |
DB01082
|
| KEGG ID |
D01350
|
| MeSH ID |
D013307
|
| PubChem ID |
19648
|
| TTD Drug ID |
D0N0EQ
|
| NDC Product Code |
51671-0009 |
| UNII |
CW25IKJ202
|
| Synonyms |
Streptomycin | Streptomycine Panpharma | Streptomycin Grünenthal | Estreptomicina CEPA | Strepto-Hefa | Strepto Hefa | Estreptomicina Clariana | Estreptomicina Normon | Strepto-Fatol | Strepto Fatol | Streptomycin Sulfate | Streptomycin Sulfate (2:3) Salt | Streptomycin Sulphate |
|
| Chemical Information |
| Molecular Formula |
C42H84N14O36S3 |
| CAS Registry Number |
3810-74-0 |
| SMILES |
CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.CC
1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.OS(=
O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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