Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Streptozocin
Drug ID BADD_D02073
Description An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Indications and Usage For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).
Marketing Status approved; investigational
ATC Code L01AD04
DrugBank ID DB00428
KEGG ID D05932
MeSH ID D013311
PubChem ID 29327
TTD Drug ID D0I8RR
NDC Product Code 67430-225; 68118-100; 0703-4636
UNII 5W494URQ81
Synonyms Streptozocin | Streptozotocine | 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose | Streptozotocin | Zanosar
Chemical Information
Molecular Formula C8H15N3O7
CAS Registry Number 18883-66-4
SMILES CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aggression19.05.01.001--Not Available
Aminoaciduria20.02.01.024; 14.14.04.003; 03.08.04.003--Not Available
Anaemia01.03.02.001--
Anuria20.01.03.002--Not Available
Aspartate aminotransferase increased13.03.04.011--
Azotaemia20.01.01.001--Not Available
Blood bilirubin increased13.03.04.018--
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Death08.04.01.001--
Diarrhoea07.02.01.001--
Eosinophilia01.02.04.001--
Erythema23.03.06.001--Not Available
Extravasation08.01.03.008--Not Available
Febrile neutropenia08.05.02.004; 01.02.03.002--
Feeling abnormal08.01.09.014--Not Available
Glucose tolerance impaired14.06.02.001; 05.06.02.001--
Glycosuria20.02.01.005--
Haematocrit decreased13.01.05.001--Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hyperchloraemia14.05.08.001--Not Available
Hypoalbuminaemia09.01.02.003; 14.10.01.002--
Hypocalcaemia14.04.01.004--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Hypophosphataemia14.04.03.001--
Injection site pain12.07.03.011; 08.02.03.010--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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