Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Succinylcholine
Drug ID BADD_D02079
Description Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups.[A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.[L9004]
Indications and Usage Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.[L9004]
Marketing Status approved
ATC Code M03AB01
DrugBank ID DB00202
KEGG ID D00766
MeSH ID D013390
PubChem ID 5314
TTD Drug ID D0Q7ZQ
NDC Product Code 43598-666; 71872-7241
UNII J2R869A8YF
Synonyms Succinylcholine | Succinyldicholine | Suxamethonium | Dicholine Succinate | Succinate, Dicholine | Quelicin | Succinylcholine Dichloride | Dichloride, Succinylcholine | Succinylcholine Dichloride, Di-H2O | Succinylcholine Dichloride, Di H2O | Succinylcholine Diiodide | Diiodide, Succinylcholine | Myorelaxin | Succinylcholine Diperchlorate | Diperchlorate, Succinylcholine | Succinylcholine Iodide | Suxamethonium Bromide | Bromide, Suxamethonium | Suxamethonium Chloride | Listenon | Succinylcholine Chloride | Anectine | Celocurine | Ditilin | Lysthenon | Succicuran | Succinylcholine Dibromide | Dibromide, Succinylcholine
Chemical Information
Molecular Formula C14H30N2O4+2
CAS Registry Number 306-40-1
SMILES C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.0010.000154%
Myalgia15.05.02.0010.000251%
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.001--
Myoglobinuria20.02.01.010; 15.05.03.009; 02.04.02.006--Not Available
Myoglobin urine present13.16.02.002--Not Available
Paralysis17.01.04.0040.000347%Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Respiratory arrest22.02.01.0090.000057%Not Available
Respiratory depression22.02.01.010; 17.02.05.0470.000057%Not Available
Respiratory distress22.02.01.0120.000154%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Rhabdomyolysis15.05.05.0020.000154%
Salivary hypersecretion07.06.01.009--Not Available
Sedation17.02.04.0050.000057%Not Available
Seizure17.12.03.0010.000256%
Shock24.06.02.002--Not Available
Sputum increased22.02.03.007--Not Available
Tachycardia02.03.02.0070.000182%Not Available
Tachyphylaxis10.02.01.050; 08.06.01.028--Not Available
Therapeutic response decreased08.06.01.016--Not Available
Therapeutic response increased08.06.01.021--Not Available
Throat tightness22.12.03.031; 19.01.02.0050.000194%Not Available
Trismus17.01.03.004; 15.05.04.004--
Urticaria23.04.02.001; 10.01.06.001--
Ventricular fibrillation02.03.04.008--
Ventricular tachycardia02.03.04.0100.000085%
Musculoskeletal discomfort15.03.04.001--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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