Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sugammadex sodium
Drug ID BADD_D02085
Description Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Indications and Usage Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.
Marketing Status approved
ATC Code V03AB35
DrugBank ID DB06206
KEGG ID D05940
MeSH ID D000077122
PubChem ID 6918584
TTD Drug ID Not Available
NDC Product Code 53296-0119; 59651-409; 69037-0050; 76397-034; 62227-016; 69575-4041; 83137-0005; 51846-1056; 11722-068; 42973-233; 69766-065; 12860-0001; 63850-8099; 71796-003; 76397-033; 16436-0119; 65129-1418; 76397-030; 62147-0278; 82393-301
UNII ERJ6X2MXV7
Synonyms Sugammadex | Org 25969 | Sugammadex Sodium | 6-Perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin sodium salt | Bridion
Chemical Information
Molecular Formula C72H104Na8O48S8
CAS Registry Number 343306-71-8
SMILES C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O) O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)[O-])CSCCC(=O)[O-] )CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])O)O)C(=O) [O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Albumin urine present13.13.02.012--Not Available
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Back pain15.03.04.005--
Beta 2 microglobulin increased13.09.01.015--Not Available
Beta 2 microglobulin urine increased13.09.01.016--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac arrest02.03.04.001--
Chills15.05.03.016; 08.01.09.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Drug hypersensitivity10.01.01.001--Not Available
Dysgeusia17.02.07.003; 07.14.03.001--
Electrocardiogram QT prolonged13.14.05.004--
Flushing24.03.01.002; 08.01.03.025; 23.06.05.003--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypotension24.06.03.002--
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Insomnia17.15.03.002; 19.02.01.002--
Laryngeal pain22.12.03.010--
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