Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sugammadex sodium
Drug ID BADD_D02085
Description Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Indications and Usage Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.
Marketing Status approved
ATC Code V03AB35
DrugBank ID DB06206
KEGG ID D05940
MeSH ID D000077122
PubChem ID 6918584
TTD Drug ID Not Available
NDC Product Code 53296-0119; 59651-409; 69037-0050; 76397-034; 62227-016; 69575-4041; 83137-0005; 51846-1056; 11722-068; 42973-233; 69766-065; 12860-0001; 63850-8099; 71796-003; 76397-033; 16436-0119; 65129-1418; 76397-030; 62147-0278; 82393-301
UNII ERJ6X2MXV7
Synonyms Sugammadex | Org 25969 | Sugammadex Sodium | 6-Perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin sodium salt | Bridion
Chemical Information
Molecular Formula C72H104Na8O48S8
CAS Registry Number 343306-71-8
SMILES C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O) O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)[O-])CSCCC(=O)[O-] )CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])O)O)C(=O) [O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Light anaesthesia25.01.03.003--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Pain08.01.08.004--
Rash erythematous23.03.13.029--Not Available
Swelling08.01.03.015--Not Available
Swollen tongue10.01.05.015; 07.14.02.003; 23.04.01.014--Not Available
Tachycardia02.03.02.007--Not Available
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Vertigo04.04.01.003; 17.02.12.002--
Vomiting07.01.07.003--
Unwanted awareness during anaesthesia12.02.20.010--Not Available
Angiopathy24.03.02.007--Not Available
Anaesthetic complication12.02.20.002--Not Available
Cardiac disorder02.11.01.003--Not Available
Connective tissue disorder10.04.04.026; 15.06.01.006--Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Postoperative wound complication12.02.05.019--Not Available
Grimacing17.02.05.029--Not Available
Procedural hypotension24.06.03.010; 12.02.05.026--Not Available
Procedural hypertension24.08.02.012; 12.02.05.037--Not Available
Procedural pain12.02.05.007; 08.01.08.009--Not Available
Recurrence of neuromuscular blockade12.02.20.009; 17.05.04.006--Not Available
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