Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Suvorexant
Drug ID BADD_D02103
Description Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Indications and Usage Suvorexant is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
Marketing Status approved; investigational
ATC Code N05CM19
DrugBank ID DB09034
KEGG ID D10082
MeSH ID C551624
PubChem ID 24965990
TTD Drug ID D00OVU
NDC Product Code 0006-0325; 0006-0001; 70966-0034; 0006-0003; 50473-0029; 0006-0002; 0006-0033; 0006-0004; 0006-0335; 0006-0005
UNII 081L192FO9
Synonyms suvorexant | (4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | methanone, ((7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)- | MK 4305 | MK4305 | MK-4305 | Belsomra
Chemical Information
Molecular Formula C23H23ClN6O2
CAS Registry Number 1030377-33-3
SMILES CC1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry mouth07.06.01.0020.001999%
Dry throat07.06.01.005; 22.12.03.0050.000444%Not Available
Dysarthria19.19.03.001; 17.02.08.0010.000353%
Dysgeusia17.02.07.003; 07.14.03.0010.000732%
Dyskinesia17.01.02.0060.000287%
Eye irritation06.04.05.0030.000444%Not Available
Eye pain06.08.03.0020.000444%
Fear19.06.03.0010.001307%Not Available
Feeling abnormal08.01.09.0140.008454%Not Available
Feeling jittery08.01.09.0160.000666%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Hallucination19.10.04.0030.003894%
Hallucination, auditory19.10.04.0040.000353%Not Available
Hallucination, visual19.10.04.0070.000196%Not Available
Hangover08.01.09.0180.001842%Not Available
Head discomfort17.02.05.0270.001777%Not Available
Headache17.14.01.0010.010937%
Hiccups22.12.01.001; 07.01.06.0090.000287%
Hyperhidrosis23.02.03.004; 08.01.03.0280.002221%
Hypersomnia19.02.05.001; 17.15.01.0010.000287%
Hyperventilation22.02.01.006; 19.01.02.0040.000444%Not Available
Hypnagogic hallucination19.02.02.001--Not Available
Hypnopompic hallucination19.02.02.006--Not Available
Increased appetite14.03.01.003; 08.01.09.0270.000666%Not Available
Infection11.01.08.002--Not Available
Initial insomnia19.02.01.005; 17.15.03.0050.001620%Not Available
Insomnia19.02.01.002; 17.15.03.0020.014203%
Interstitial lung disease22.01.02.003; 10.02.01.0330.000196%Not Available
Irritability19.04.02.013; 08.01.03.0110.001085%
Memory impairment19.20.01.003; 17.03.02.0030.001150%
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