Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Suvorexant
Drug ID BADD_D02103
Description Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.
Indications and Usage Suvorexant is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
Marketing Status approved; investigational
ATC Code N05CM19
DrugBank ID DB09034
KEGG ID D10082
MeSH ID C551624
PubChem ID 24965990
TTD Drug ID D00OVU
NDC Product Code 0006-0325; 0006-0001; 70966-0034; 0006-0003; 50473-0029; 0006-0002; 0006-0033; 0006-0004; 0006-0335; 0006-0005
UNII 081L192FO9
Synonyms suvorexant | (4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone | methanone, ((7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)- | MK 4305 | MK4305 | MK-4305 | Belsomra
Chemical Information
Molecular Formula C23H23ClN6O2
CAS Registry Number 1030377-33-3
SMILES CC1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Suicidal ideation19.12.01.0030.000719%
Suicide attempt19.12.01.0040.000523%
Therapeutic response decreased08.06.01.0160.001111%Not Available
Therapeutic response unexpected08.06.01.0010.001999%Not Available
Thinking abnormal19.10.03.001; 17.02.05.0230.000575%Not Available
Thirst14.03.02.007; 08.01.09.0210.000287%Not Available
Throat tightness22.12.03.031; 19.01.02.0050.000444%Not Available
Tinnitus17.04.07.004; 04.04.01.0020.000889%
Toothache07.09.06.0010.000287%
Tremor17.01.06.0020.002260%
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary retention20.02.02.0110.000327%
Paradoxical drug reaction08.06.01.0140.000287%Not Available
Depressive symptom19.15.02.0030.000131%Not Available
Adverse event08.06.01.0100.004560%Not Available
Feeding disorder19.09.01.003; 14.03.02.0030.000287%Not Available
Infestation23.11.01.002; 11.09.01.001--Not Available
Limb discomfort15.03.04.0140.000444%Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.0020.000575%Not Available
Abnormal behaviour19.01.01.0010.000418%Not Available
Ill-defined disorder08.01.03.0490.001398%Not Available
Abnormal sleep-related event19.02.03.009; 17.15.02.0070.000666%Not Available
Poor quality sleep19.02.05.005; 17.15.04.0020.005971%Not Available
Suicidal behaviour19.12.01.0060.000131%Not Available
Adverse reaction08.06.01.0180.000444%Not Available
Terminal insomnia17.15.03.004; 19.02.01.0040.000797%Not Available
Tachyphrenia19.10.03.010; 17.03.03.0070.000444%Not Available
Sleep sex19.02.03.011; 17.15.02.0080.000131%Not Available
Drug effect less than expected08.06.01.0360.000666%Not Available
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