Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tacrine hydrochloride
Drug ID BADD_D02104
Description A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
Indications and Usage For the palliative treatment of mild to moderate dementia of the Alzheimer's type.
Marketing Status approved; investigational; withdrawn
ATC Code N06DA01
DrugBank ID DB00382
KEGG ID D02068
MeSH ID D013619
PubChem ID 2723754
TTD Drug ID D0E6YQ
NDC Product Code Not Available
UNII 4966RNG0BU
Synonyms Tacrine | 9-Amino-1,2,3,4-Tetrahydroacridine | 1,2,3,4-Tetrahydro-9-acridinamine | Tetrahydroaminoacridine | 1,2,3,4-Tetrahydroaminoacridine | Romotal | Tenakrin | THA | Cognex | Tacrine Hydrochloride
Chemical Information
Molecular Formula C13H15ClN2
CAS Registry Number 1684-40-8
SMILES C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Facial paralysis17.04.03.008--Not Available
Fall12.01.08.002--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Flushing08.01.03.025; 24.03.01.002; 23.06.05.003--
Fracture15.08.02.001; 12.04.02.001--
Furuncle23.11.02.009; 11.02.05.008--Not Available
Gastric ulcer07.04.03.002--
Gastritis07.08.02.001--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Generalised oedema14.05.06.007; 08.01.07.004--
Gingivitis07.09.10.002; 11.01.04.013--
Glaucoma06.03.01.002--
Glossitis07.14.01.001--Not Available
Glycosuria20.02.01.005--
Gout15.01.06.001; 14.09.01.001--Not Available
Haematochezia07.12.02.003; 24.07.02.012--Not Available
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
Haemolysis01.06.04.002--
Haemoptysis02.11.04.009; 24.07.01.006; 22.02.03.004--Not Available
Haemorrhoids24.10.02.002; 07.15.03.001--
Hallucination19.10.04.003--
Headache17.14.01.001--
Heat exhaustion12.05.01.003--Not Available
Hemiplegia17.01.04.002--Not Available
Herpes simplex23.11.05.004; 11.05.02.001--Not Available
Herpes zoster11.05.02.003; 23.11.05.005; 17.09.03.026--
Hiatus hernia22.09.02.004; 07.16.01.001--Not Available
Hordeolum11.01.06.002; 06.04.04.006--Not Available
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 8 Pages