Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tacrine hydrochloride
Drug ID BADD_D02104
Description A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
Indications and Usage For the palliative treatment of mild to moderate dementia of the Alzheimer's type.
Marketing Status approved; investigational; withdrawn
ATC Code N06DA01
DrugBank ID DB00382
KEGG ID D02068
MeSH ID D013619
PubChem ID 2723754
TTD Drug ID D0E6YQ
NDC Product Code Not Available
UNII 4966RNG0BU
Synonyms Tacrine | 9-Amino-1,2,3,4-Tetrahydroacridine | 1,2,3,4-Tetrahydro-9-acridinamine | Tetrahydroaminoacridine | 1,2,3,4-Tetrahydroaminoacridine | Romotal | Tenakrin | THA | Cognex | Tacrine Hydrochloride
Chemical Information
Molecular Formula C13H15ClN2
CAS Registry Number 1684-40-8
SMILES C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hostility19.05.01.003--Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkeratosis23.01.01.001--
Hyperkinesia17.01.02.008--Not Available
Hypertension24.08.02.001--
Hyperthyroidism14.11.01.011; 05.02.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hyperventilation19.01.02.004; 22.02.01.006--Not Available
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hyporeflexia17.02.01.003--
Hypotension24.06.03.002--
Hypothyroidism05.02.03.001; 14.11.01.012--
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intestinal obstruction07.13.01.002--Not Available
Kidney infection20.01.09.004; 11.01.14.006--
Labyrinthitis11.01.05.002; 04.04.03.001--Not Available
Leukopenia01.02.02.001--Not Available
Libido increased21.03.02.007; 19.08.03.002--
Lipoma16.18.01.001; 15.09.01.001--Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.002--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.003--
Malignant melanoma23.08.01.001; 16.03.01.001--Not Available
Micturition urgency20.02.02.006--
Migraine24.03.05.003; 17.14.02.001--Not Available
Movement disorder17.01.02.010--Not Available
Muscle twitching15.05.03.005--Not Available
Myalgia15.05.02.001--
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