Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tafluprost
Drug ID BADD_D02108
Description A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.
Indications and Usage Tafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Marketing Status approved
ATC Code S01EE05
DrugBank ID DB08819
KEGG ID D06274
MeSH ID C485333
PubChem ID 9868491
TTD Drug ID D04LCQ
NDC Product Code 82584-609; 61556-080; 65035-137; 54893-0021; 63190-0590; 76397-013; 65302-062; 68245-0012; 75872-0001; 66993-429; 0781-6184; 70390-0001; 17478-609
UNII 1O6WQ6T7G3
Synonyms tafluprost | 1-methylethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate | AFP-168
Chemical Information
Molecular Formula C25H34F2O5
CAS Registry Number 209860-87-7
SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lacrimation increased06.08.02.0040.001462%
Lymphoma16.20.01.001; 01.12.01.0010.000107%Not Available
Macular oedema06.04.06.0050.000107%Not Available
Muscle spasms15.05.03.0040.000365%
Myocardial infarction24.04.04.009; 02.02.02.0070.000161%
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Neoplasm malignant16.16.01.0010.000161%Not Available
Nervous system disorder17.02.10.001--Not Available
Ocular hyperaemia06.04.05.0040.010102%Not Available
Photophobia06.01.01.004; 17.17.02.0060.001698%
Pruritus23.03.12.0010.000473%
Punctate keratitis06.04.02.003--Not Available
Retinal detachment12.01.04.004; 06.09.03.0030.000161%
Rhinitis22.07.03.006; 11.01.13.004--
Skin discolouration23.03.03.0050.000365%Not Available
Tinnitus04.04.01.002; 17.04.07.0040.000419%
Urinary tract infection20.08.02.001; 11.01.14.004--
Uveitis10.02.01.023; 06.04.03.003--
Vision blurred17.17.01.010; 06.02.06.0070.001150%
Visual acuity reduced17.17.01.011; 06.02.10.0120.000365%
Visual impairment06.02.10.0130.000398%Not Available
Wheezing22.03.01.0090.000236%
Growth of eyelashes06.06.04.0070.000107%Not Available
Iris hyperpigmentation06.06.06.001--Not Available
Foreign body sensation in eyes06.01.01.0060.001096%Not Available
Conjunctival hyperaemia06.04.01.0040.000548%Not Available
Eyelids pruritus23.03.12.005; 06.08.03.0070.000731%Not Available
Eye pruritus06.04.05.0060.003708%Not Available
Ocular discomfort06.08.03.0080.000548%Not Available
Eyelid irritation23.03.04.023; 06.04.04.0070.000913%Not Available
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