| Pharmaceutical Information |
| Drug Name |
Tamsulosin hydrochloride |
| Drug ID |
BADD_D02114 |
| Description |
Tamsulosin is a selective alpha-1A and alpha-1B adrenoceptor antagonist that exerts its greatest effect in the prostate and bladder, where these receptors are most common.[Label] It is indicated for the treatment of signs and symptoms of benign prostatic hypertrophy.[Label] Antagonism of these receptors leads to relaxation of smooth muscle in the prostate and detrusor muscles in the bladder, allowing for better urinary flow.[Label] Other alpha-1 adrenoceptor antagonists developed in the 1980s were less selective and more likely to act on the smooth muscle of blood vessels, resulting in hypotension.[A178351]
Tamsulosin was first approved by the FDA on April 15, 1997.[L6238] |
| Indications and Usage |
Tamsulosin is indicated for the treatment of signs and symptoms of benign prostatic hyperplasia.[Label]
Tamsulosin is also used off label for the treatment of ureteral stones, prostatitis, and female voiding dysfunction.[A178339,L6259] |
| Marketing Status |
approved; investigational |
| ATC Code |
G04CA02 |
| DrugBank ID |
DB00706
|
| KEGG ID |
D01024
|
| MeSH ID |
D000077409
|
| PubChem ID |
5362376
|
| TTD Drug ID |
D05MBZ
|
| NDC Product Code |
73750-099; 50090-5553; 65841-695; 67296-1319; 67296-1850; 68071-2561; 68788-7050; 70518-2052; 70934-092; 0781-2076; 49629-011; 62331-024; 60760-450; 67296-1803; 68382-132; 72603-115; 12838-2788; 65129-2074; 65841-118; 33342-159; 43063-264; 58118-0598; 61919-703; 63187-358; 67877-450; 70518-2541; 71335-0398; 55700-670; 63739-567; 71205-217; 71335-0711; 43063-725; 55154-7649; 67296-1155; 82009-025; 43579-011; 65862-298; 0024-5837; 57237-014; 60760-598; 65862-598; 67296-1739; 68071-4443; 51655-832; 68071-1934; 68071-3467; 71335-1538; 53069-0860; 68022-7005; 43353-019; 63187-371; 63187-469; 70518-1417; 70934-969; 71205-748; 43353-013; 62756-160; 63629-8135; 64679-516; 68084-299; 70518-0179; 71335-1784; 53296-0073; 16714-713; 43063-947; 68071-2859; 68788-7780; 71205-688; 0615-8055; 0904-6401; 17511-118; 53747-018; 50268-740; 0228-2996 |
| UNII |
11SV1951MR
|
| Synonyms |
Tamsulosin | LY 253352 | LY-253352 | Tamsulosin Hydrochloride | 5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide | Flomax | YM 617 | YM-617 |
|
| Chemical Information |
| Molecular Formula |
C20H29ClN2O5S |
| CAS Registry Number |
106463-17-6 |
| SMILES |
CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl |
| Chemical Structure |
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| ADRs Induced by Drug |
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