| Pharmaceutical Information |
| Drug Name |
Technetium tc-99m exametazime |
| Drug ID |
BADD_D02126 |
| Description |
Technetium Tc-99m exametazime is a radiopharmaceutical sold under the trade name Ceretec used in the detection of altered regional cerebral perfusion in stroke and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections and inflammatory bowel disease. Exametazime, also known as hexamethylpropyleneamine oxime or HMPAO, acts as a chelating agent for the Tc-99m radioisotope. |
| Indications and Usage |
Technetium Tc99m exametazime scintigraphy (with or without methylene blue stabilization) may be useful as an adjunct in the detection of altered regional cerebral perfusion in stroke. Tc99m exametazime without methylene blue stabilization is indicated for leukocyte labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease. |
| Marketing Status |
approved |
| ATC Code |
Not Available |
| DrugBank ID |
DB09163
|
| KEGG ID |
D02284
|
| MeSH ID |
D019690
|
| PubChem ID |
129626367
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
17156-022 |
| UNII |
3B744AG22N
|
| Synonyms |
Technetium Tc 99m Exametazime | Tc-99m-Exametazime | Tc 99m Exametazime | 99m-Tc-HMPAO | 99mTc-HMPAO | Technetium Tc 99m Hexamethylpropylene-amine Oxime | Technetium Tc 99m Hexamethylpropylene amine Oxime | Tc-99m-Hexamethylpropyleneamine Oxime | Tc 99m Hexamethylpropyleneamine Oxime | Technetium Tc 99m Hexamethylpropyleneamine Oxime | Tc-99m HMPAO | Ceretec |
|
| Chemical Information |
| Molecular Formula |
C13H25N4O3Tc |
| CAS Registry Number |
99944-78-2 |
| SMILES |
CC(C(=NO)C)[N-]CC(C)(C)C[N-]C(C)C(=N[O-])C.O=[Tc+3] |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Blood pressure increased | 13.14.03.005 | - | - | Not Available | | Erythema | 23.03.06.001 | - | - | Not Available | | Face oedema | 23.04.01.004; 10.01.05.002; 08.01.07.003 | - | - | | | Pyrexia | 08.05.02.003 | - | - | | | Rash | 23.03.13.001 | - | - | Not Available |
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