Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Technetium tc-99m sestamibi
Drug ID BADD_D02132
Description Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and/or breast tissue. The mechanism by which sestamibi localizes to these tissues has not been established. Single photon emission computed tomography (SPECT) is then performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99. Currently available within a preparation kit for injection, Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
Indications and Usage Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB09161
KEGG ID D01060; D08763
MeSH ID D017256
PubChem ID 5384
TTD Drug ID D0J1TU
NDC Product Code 45567-0555
UNII 971Z4W1S09
Synonyms Technetium Tc 99m Sestamibi | Tc-99m-Methoxy-2-isobutylisonitrile | Tc 99m Methoxy 2 isobutylisonitrile | Technetium-99m-Hexamibi | Technetium 99m Hexamibi | Tc MIBI | 99mTc-Hexamibi | 99mTc Hexamibi | 99mTc-Sestamibi | 99mTc Sestamibi | Technetium Tc 99m 2-Methoxy-2-methylpropylisonitrile | Technetium Tc 99m 2 Methoxy 2 methylpropylisonitrile | Technetium-99m-Sestamibi | Technetium 99m Sestamibi | Cardiolite | Technetium Tc 99m Sestamibi Chloride
Chemical Information
Molecular Formula C36H72N6O6Tc
CAS Registry Number 109581-73-9
SMILES CC(C)(CN=[CH-])OC.CC(C)(CN=[CH-])OC.CC(C)(CN=[CH-])OC.CC(C)(CN=[CH-])OC.CC(C)(CN =[CH-])OC.CC(C)(CN=[CH-])OC.[Tc+6]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Mental disorder19.07.01.002--Not Available
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