| Pharmaceutical Information |
| Drug Name |
Technetium tc-99m sodium pertechnetate |
| Drug ID |
BADD_D02133 |
| Description |
Technetium Tc-99m pertechnetate is a radiopharmaceutical diagnostic agent composed of an oxoanion with the chemical formula TcO4-. Pertechnetate has a wide variety of uses within nuclear medicine as it distributes within the body to a similar extent as iodine. It also concentrates in the thyroid gland, salivary glands, gastric mucosa, and choroid plexus. However, in contrast to the iodide ion, the pertechnetate ion is released unchanged from the thyroid gland. Currently marketed as the product Drytec, technetium-99m pertechnetate is indicated for imaging of the following tissues: thyroid, salivary gland, urinary bladder (for detection of vesico-ureteral reflux), and the nasolacrimal drainage system.
Technetium-99m's short half life (6 hours) makes storage impossible, therefore it is supplied as its parent nuclide molybdenum-99, which spontaneously decays to technetium-99 through beta decay. This is normally supplied in a hospital setting through the use of a technetium-99m generator, whereby technetium exits the generator in the form of the pertechnetate ion, TcO4−, which can be extracted and promptly used for clinical diagnostics. Following intravenous injection, single photon emission computed tomography (SPECT) is performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99. |
| Indications and Usage |
Sodium Pertechnetate Tc99m Injection is indicated for use in adults for imaging in the following tissues: thyroid, salivary gland, urinary bladder (for detection of vesico-ureteral reflux), and nasolacrimal drainage system (dacryoscintigraphy). It is indicated for use in children for imaging the following tissues: thyroid and urinary bladder.
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| Marketing Status |
approved; investigational |
| ATC Code |
Not Available |
| DrugBank ID |
DB09314
|
| KEGG ID |
Not Available
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| MeSH ID |
D013670
|
| PubChem ID |
23689036
|
| TTD Drug ID |
D0BP4Y
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| NDC Product Code |
Not Available |
| UNII |
A0730CX801
|
| Synonyms |
Sodium Pertechnetate Tc 99m | Technetium Tc 99m Pertechnetate | 99mTcO4 | Technetium-99mTc-pertechnetate | Technetium 99mTc pertechnetate | Tc 99m-Pertechnetate | 99m-Pertechnetate, Tc | Tc 99m Pertechnetate | Technetium Tc 99m O(4) | 99Tc-Pertechnetate | 99Tc Pertechnetate | 99TcmO4 | Pertechnetate | Technetium Pertechnetate | Pertechnetate, Technetium | Pertechnetate Sodium | Sodium, Pertechnetate |
|
| Chemical Information |
| Molecular Formula |
NaO4Tc |
| CAS Registry Number |
23288-60-0 |
| SMILES |
[O-][Tc](=O)(=O)=O.[Na+] |
| Chemical Structure |
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| ADRs Induced by Drug |
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