| Pharmaceutical Information |
| Drug Name |
Telavancin |
| Drug ID |
BADD_D02143 |
| Description |
Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and subcutaneous tissue infections among others. |
| Indications and Usage |
For the treatment of complicated skin and skin structure infections (cSSSI) caused by gram-positive bacteria like methicillin-susceptible or -resistant Staphylococcus aureus, vancomycin-susceptible Enterococcus faecalis, and Streptococcus pyogenes, Streptococcus agalactiae, or Streptococcus anginosus group. Also for the treatment of adult patients with hospital-acquired bacterial pneumonia (HAP) and ventilator-associated bacterial pneumonia (VAP), known or suspected to be caused by susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant S. aureus). |
| Marketing Status |
approved |
| ATC Code |
J01XA03 |
| DrugBank ID |
DB06402
|
| KEGG ID |
D06057
|
| MeSH ID |
C487637
|
| PubChem ID |
3081362
|
| TTD Drug ID |
D0B9JO
|
| NDC Product Code |
71124-0005 |
| UNII |
XK134822Z0
|
| Synonyms |
telavancin | TD 6424 | TD6424 | TD-6424 | Vibativ | telavancin hydrochloride |
|
| Chemical Information |
| Molecular Formula |
C80H106Cl2N11O27P |
| CAS Registry Number |
372151-71-8 |
| SMILES |
CCCCCCCCCCNCCNC1(CC(OC(C1O)C)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)N
C(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C(=C(C=C9C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)
O)NC7=O)C(=O)O)O)CNCP(=O)(O)O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)C |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
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