| Drug Name |
Terbinafine hydrochloride |
| Drug ID |
BADD_D02161 |
| Description |
Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.[A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.[A1279,A1281,L9068]
Terbinafine hydrochloride was granted FDA approval on 30 December 1992.[L9064] |
| Indications and Usage |
Terbinafine hydrochloride is indicated to treat fungal skin and nail infections caused by _Trichophyton_ species, _Microsporum canis_, _Epidermophyton floccosum_,[L9068] and _Tinea_ species.[L9065] Terbinafine hydrochloride also treats yeast infections of the skin caused by _Candida_ species and _Malassezia furfur_.[L9068] |
| Marketing Status |
approved; investigational; vet_approved |
| ATC Code |
D01AE15; D01BA02 |
| DrugBank ID |
DB00857
|
| KEGG ID |
D02219
|
| MeSH ID |
D000077291
|
| PubChem ID |
5282481
|
| TTD Drug ID |
D01AYJ
|
| NDC Product Code |
82982-046; 49386-007; 49452-7627; 56062-080; 61047-120; 61919-451; 71335-0918; 53069-0530; 59349-0007; 24385-524; 51672-2083; 14501-0012; 52562-600; 55111-024; 65862-364; 50066-080; 0363-2080; 63629-1993; 68071-2579; 71335-9677; 55111-250; 63187-111; 69452-351; 71205-061; 71205-492; 71335-0257; 62991-3085; 66039-859; 70159-006; 41250-080; 43063-598; 50090-1278; 51991-526; 65862-079; 68016-080; 70518-2941; 71335-1836; 38779-3253; 48087-0079; 59349-0037; 53002-0550; 60429-222; 68071-1640; 68788-9814; 71335-1124; 38779-2481; 45201-526; 51927-4856; 59349-0038; 66039-817; 43353-893; 49035-080; 50066-208; 50090-5810; 0067-3998; 0067-6297; 11822-0080; 50090-3575; 51672-2140; 68788-7187; 71205-127; 53104-7577; 68554-0002; 21130-080; 41520-080; 49348-790; 59779-080; 0363-2083; 70000-0338; 70677-1003; 70934-947; 0067-8114; 66219-0001; 37808-080; 42043-410; 63187-792; 63629-8137; 68071-4500; 68788-7450; 0067-3999; 0067-6296; 0067-8100; 52286-0007; 69037-0049; 73309-177; 16714-795; 30142-080; 36800-080; 43063-906; 51672-2080 |
| UNII |
012C11ZU6G
|
| Synonyms |
Terbinafine | Terbinafine, (Z)-isomer | Terbinafine, (Z)- | Lamisil | (E)-N-(6,6-Dimethyl-2-heptenynyl)-N-methyl-1-naphthalenementhamin hydrochloride | TDT-067 | TDT 067 | TDT067 | DA 5505 | SF 86-327 | SF 86 327 | SF 86327 | SF-86-327 | SF86327 | Terbinafine Hydrochloride |
