Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Testosterone cypionate
Drug ID BADD_D02171
Description Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. It was developed by the company Pharmacia and Upjohn and FDA approved on July 25, 1979.
Indications and Usage Testosterone cypionate is used in males that present conditions derived from a deficiency or absence of endogenous testosterone. These conditions are 1) primary hypogonadism, defined as the testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome or orchidectomy; and 2) hypogonadotropic hypogonadism characterized by idiopathic gonadotropin, LHRH deficiency or pituitary-hypothalamic injury from tumors, trauma or radiation.[L1153]
Marketing Status approved
ATC Code Not Available
DrugBank ID DB13943
KEGG ID D00957
MeSH ID C016131
PubChem ID 441404
TTD Drug ID Not Available
NDC Product Code 60870-0252; 64025-0021; 0009-0086; 0143-9726; 52536-625; 62756-016; 0409-6562; 70700-288; 46439-8736; 62991-3132; 48087-0096; 0143-9659; 69097-536; 69097-802; 70700-289; 0574-0827; 76420-065; 51927-0189; 73774-016; 0591-4128; 38779-0164; 46204-0371; 60722-3016; 47781-911; 62756-015; 69097-537; 0143-9005; 63629-8706; 70700-290; 71225-127; 0009-0027; 47781-910; 63187-647; 63629-8705; 0517-1830; 51927-2706; 65089-0049; 73301-010; 0009-0347; 49803-006; 51552-0104; 63275-9982; 82393-114; 62756-017; 0409-6557; 0574-0820; 71205-289; 22552-0010; 43647-678; 0009-0085; 0009-0417; 50090-4147
UNII M0XW1UBI14
Synonyms testosterone 17 beta-cypionate | testosterone cypionate | testosterone 17 beta-cyclopentanepropionate | testosterone 17 beta-cyclopentylpropionate | Depo-Testosterone | Depo-Testosterone Cypionate | deposteron | Duratest | Testa-C | Testex Elmu | Andronate | Depostomead
Chemical Information
Molecular Formula C27H40O3
CAS Registry Number 58-20-8
SMILES CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=CC(=O)CCC35C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Sodium retention14.05.04.003--Not Available
Speech disorder19.19.02.002; 17.02.08.003; 22.12.03.0270.003145%Not Available
Stress19.06.02.0040.002831%Not Available
Testicular pain21.13.01.0050.002307%
Therapeutic response decreased08.06.01.016--Not Available
Therapeutic response unexpected08.06.01.0010.004089%Not Available
Thrombosis24.01.01.0060.022227%Not Available
Transient ischaemic attack24.04.06.005; 17.08.04.0010.009436%
Ventricular tachycardia02.03.04.0100.002097%
Visual field defect17.17.01.001; 06.02.07.0030.001573%Not Available
Mobility decreased15.03.05.023; 17.02.05.018; 08.01.03.0300.002097%Not Available
Seasonal allergy10.01.04.001; 22.04.04.008; 06.04.01.0130.008912%Not Available
Spontaneous penile erection21.03.01.010--Not Available
Sudden cardiac death08.04.01.008; 02.03.04.0160.001573%Not Available
General physical health deterioration08.01.03.0180.002097%Not Available
Balance disorder17.02.02.007; 08.01.03.0810.003669%Not Available
Abnormal clotting factor01.01.02.005--Not Available
Deep vein thrombosis24.01.02.0030.038477%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.0150.001573%Not Available
Ocular vascular disorder24.03.07.005; 06.07.02.0020.001048%Not Available
Injection site swelling12.07.03.018; 08.02.03.0170.029146%Not Available
Injection site discomfort12.07.03.019; 08.02.03.0180.008912%Not Available
Metaplasia08.03.04.0040.008387%Not Available
Haemorrhage24.07.01.002--Not Available
Temperature intolerance08.01.09.0220.001573%Not Available
Bipolar disorder19.16.01.0030.001048%Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.001573%
Injection site nodule08.02.03.034; 23.07.04.009; 12.07.03.0340.005347%Not Available
Dysgraphia17.02.03.0060.001573%Not Available
Prostate cancer21.04.02.002; 16.25.01.0010.001573%Not Available
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