| Pharmaceutical Information |
| Drug Name |
Tetracosactide |
| Drug ID |
BADD_D02178 |
| Description |
Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration. |
| Indications and Usage |
For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency. |
| Marketing Status |
approved |
| ATC Code |
H01AA02 |
| DrugBank ID |
DB01284
|
| KEGG ID |
D00284
|
| MeSH ID |
D003366
|
| PubChem ID |
16133802
|
| TTD Drug ID |
D0W6LI
|
| NDC Product Code |
55463-0015 |
| UNII |
72YY86EA29
|
| Synonyms |
Cosyntropin | ACTH 1-24 | Corticotropin (1-24)-Peptide | Corticotropin (1-24)-Tetracosapeptide | ACTH (1-24) | Tetracosactide | Tetracosactrin | Tetracosapeptide | 1-24-Corticotropin | 1-24-ACTH | Synthetic ACTH | ACTH, Synthetic | Cortrosyn | Cortosyn |
|
| Chemical Information |
| Molecular Formula |
C136H210N40O31S |
| CAS Registry Number |
16960-16-0 |
| SMILES |
CC(C)C(C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)
C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=C(C=C2)O)C(
=O)N3CCCC3C(=O)O)NC(=O)C4CCCN4C(=O)C(CCCCN)NC(=O)CNC(=O)C(CC5=CNC6=CC=CC=C65)NC(
=O)C(CCCNC(=N)N)NC(=O)C(CC7=CC=CC=C7)NC(=O)C(CC8=CNC=N8)NC(=O)C(CCC(=O)O)NC(=O)C
(CCSC)NC(=O)C(CO)NC(=O)C(CC9=CC=C(C=C9)O)NC(=O)C(CO)N |
| Chemical Structure |
|
|
| ADRs Induced by Drug |
|
|
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
|
|
|
