| Pharmaceutical Information |
| Drug Name |
Tetradecyl hydrogen sulfate (ester) |
| Drug ID |
BADD_D02182 |
| Description |
Sodium tetradecyl sulfate is an anionic surface-active agent which is used for its wetting properties in the industry and is also used in medicine as a blood vessel irritant and sclerosing agent for hemorrhoids and varicose veins [L2031].
Sodium tetradecyl sulfate has been widely used since the 1950s, and in 1978 the first successful report of injecting a 1% solution into spider angiomas in 144 patients was made. Also noted was an unspecified number of episodes of epidermal necrosis without significant long-term effects and a 30% incidence of post-sclerosis pigmentation that resolved within a few months [L2035]. |
| Indications and Usage |
Sotradecol (sodium tetradecyl sulfate injection) is indicated in the treatment of small, uncomplicated varicose veins of the legs showing simple dilation, with competent valves [L2030].
Sodium tetradecyl sulfate has been designated as an orphan drug by the FDA for the treatment of gastrointestinal bleeding due to esophageal varices [L2041].
|
| Marketing Status |
approved |
| ATC Code |
C05BB04 |
| DrugBank ID |
DB11328
|
| KEGG ID |
D06882
|
| MeSH ID |
D012981
|
| PubChem ID |
8771
|
| TTD Drug ID |
D0Z5SM
|
| NDC Product Code |
67457-163; 67457-162 |
| UNII |
6326W0DRHY
|
| Synonyms |
Sodium Tetradecyl Sulfate | Sulfate, Sodium Tetradecyl | Tetradecyl Sulfate, Sodium | Tergitol 4 | Trombavar | Trombovar | Sotradecol Sodium | Sotradecol |
|
| Chemical Information |
| Molecular Formula |
C14H30O4S |
| CAS Registry Number |
300-52-7 |
| SMILES |
CCCCC(CC)CCC(CC(C)C)OS(=O)(=O)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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