| Drug Name |
Tetrahydrobiopterin |
| Drug ID |
BADD_D02185 |
| Description |
Sapropterin (tetrahydrobiopterin or BH4) is a cofactor in the synthesis of nitric oxide. It is also essential in the conversion of phenylalanine to tyrosine by the enzyme phenylalanine-4-hydroxylase; the conversion of tyrosine to L-dopa by the enzyme tyrosine hydroxylase; and conversion of tryptophan to 5-hydroxytryptophan via tryptophan hydroxylase. |
| Indications and Usage |
For the treatment of tetrahydrobiopterin (BH4) deficiency. |
| Marketing Status |
approved; investigational |
| ATC Code |
A16AX07 |
| DrugBank ID |
DB00360
|
| KEGG ID |
D01798; D08505
|
| MeSH ID |
C003402
|
| PubChem ID |
135402045
|
| TTD Drug ID |
D0Q9YT
|
| NDC Product Code |
Not Available |
| UNII |
KN729W3LR0
|
| Synonyms |
sapropterin | 6R-BH4 | tetrahydrobiopterin | 5,6,7,8-erythro-tetrahydrobiopterin | tetrahydro-6-biopterin | phenylalanine hydroxylase cofactor | 5,6,7,8-tetrahydrodictyopterin | D-threo-tetrahydrobiopterin | 5,6,7,8-tetrahydro-L-erythrobiopterin | sapropterin dihydrochloride | 2,4,5-trihydroxybutyrophenone | THBP | 1-butanone, 1-(2,4,5-trihydroxyphenyl) | trihydroxybutyrophenone | 2',4',5'-trihydroxybutyrophenone | 6R-L-erythro-5,6,7,8-tetrahydrobiopterin | 5,6,7,8-tetrahydrobiopterin, (S-(R*,S*))-isomer | 5,6,7,8-tetrahydrobiopterin | kuvan |
