| Pharmaceutical Information |
| Drug Name |
Tetryzoline |
| Drug ID |
BADD_D02191 |
| Description |
Tetryzoline, also known as tetrahydrozoline, is a derivative of imidazoline with central and peripheral alpha (α)-adrenergic properties.[A231769] Available since the 1950s, tetryzoline is a selective α1-receptor agonist [A231774] that is used as an ocular and nasal decongestant. Tetryzoline is found in a wide array of over-the-counter eye drops, including the most common brand, Visine.[L32579] Tetryzoline is also found in combination products with other lubricants and anti-irritants, such as [povidone], [polyethylene glycol 400], [dextran], and [zinc sulfate].[L32584, L32589, L32594] It is also used in combination with other drug classes, such as antihistamines, corticosteroids, and glucocorticoids in other countries. Tetryzoline is also found in nasal spray under the trade name Tyzine, which is used for decongestion of nasal and nasopharyngeal mucosa.[L32599]
As it causes profound sedation in children and adults, tetryzoline is increasingly becoming scrutinized for possible drug overdose and toxicity from accidental ingestion.[A7045, A231769] It has also been misused for non-therapeutic purposes as a causative drug for several cases of drug-facilitated sexual assault.[A231764] |
| Indications and Usage |
Tetryzoline is indicated for the temporary relief of discomfort and redness of the eye due to minor eye irritations as monotherapy [L32579] or in combination with other eye lubricants and anti-irritants.[L32584, L32589, L32594]
Tetryzoline is also indicated for decongestion of nasal and nasopharyngeal mucosa.[L32599] |
| Marketing Status |
approved |
| ATC Code |
R01AA06; R01AB03; S01GA02 |
| DrugBank ID |
DB06764
|
| KEGG ID |
D08578
|
| MeSH ID |
C005810
|
| PubChem ID |
5419
|
| TTD Drug ID |
D05IHU
|
| NDC Product Code |
Not Available |
| UNII |
S9U025Y077
|
| Synonyms |
tetrahydrozoline | 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline | tetryzoline | Vispring | Collyrium Fresh | Diabenyl T | Eye-Sine | Eye-Zine | Murine Plus | Murine Sore Eyes | Ophtalmin | Optazine Fresh | Optigene | Rhinopront | Tetra-Ide | Tetraclear | tetrahydrozoline hydrochloride | tetrahydrozoline monohydrochloride | tetrahydrozoline, (+-)-isomer | tetrahydrozoline, (-)-isomer | Tetrilin | Tyzine | Vasopos | Visine | Yxin | Berberil N | Caltheon |
|
| Chemical Information |
| Molecular Formula |
C13H16N2 |
| CAS Registry Number |
84-22-0 |
| SMILES |
C1CC(C2=CC=CC=C2C1)C3=NCCN3 |
| Chemical Structure |
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| ADRs Induced by Drug |
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