Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Timolol
Drug ID BADD_D02219
Description Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
Indications and Usage Ophthalmic timolol is indicated for the treatment of increased intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The oral form of this drug is used to treat high blood pressure.[L6724,L6727] In certain cases, timolol is used in the prevention of migraine headaches.[A179530,L6742]
Marketing Status approved
ATC Code C07AA06; S01ED01
DrugBank ID DB00373
KEGG ID D00378; D08600
MeSH ID D013999
PubChem ID 33624
TTD Drug ID D05UVD
NDC Product Code 82584-001; 82584-002; 76478-001; 17478-189; 76478-002
UNII 817W3C6175
Synonyms Timolol | Timolol Maleate | Timolol Maleate, (1:1) Salt | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol | 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)- | Timoptic | Timoptol | Timacar | Timolol Hemihydrate | Blocadren | L-714,465 | L 714,465 | L714,465 | MK-950 | MK 950 | MK950 | Optimol
Chemical Information
Molecular Formula C13H24N4O3S
CAS Registry Number 26839-75-8
SMILES CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.0010.000100%
Cardiac failure acute02.05.01.005--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cataract06.06.01.0010.000201%
Catatonia19.11.01.001--Not Available
Cerebral ischaemia17.08.01.005; 24.04.06.003--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cerebrovascular disorder24.03.05.002; 17.08.02.002--Not Available
Chest discomfort02.02.02.009; 22.12.02.002; 08.01.08.019--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Choroidal detachment12.01.04.006; 06.09.01.003--Not Available
Colitis ischaemic07.08.01.004; 24.04.08.012--Not Available
Conduction disorder02.03.01.0080.000100%
Confusional state19.13.01.001; 17.02.03.005--
Conjunctival oedema06.04.01.0010.000100%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Cough22.02.03.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.0020.000341%Not Available
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006--
Drug hypersensitivity10.01.01.0010.000782%Not Available
Drug ineffective08.06.01.0060.001244%Not Available
Drug interaction08.06.03.0010.000642%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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