Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Timolol maleate
Drug ID BADD_D02220
Description Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
Indications and Usage Ophthalmic timolol is indicated for the treatment of increased intraocular pressure in patients with ocular hypertension or open-angle glaucoma. The oral form of this drug is used to treat high blood pressure.[L6724,L6727] In certain cases, timolol is used in the prevention of migraine headaches.[A179530,L6742]
Marketing Status approved
ATC Code S01ED01; C07AA06
DrugBank ID DB00373
KEGG ID D00603
MeSH ID D013999
PubChem ID 5281056
TTD Drug ID D05UVD
NDC Product Code 82260-812; 82260-819; 11722-076; 49452-7813; 24208-813; 50742-287; 59651-313; 61314-225; 61314-226; 64980-514; 68682-045; 70756-654; 51927-2003; 24208-498; 24208-812; 50090-1852; 60758-801; 68682-812; 68682-813; 70756-656; 54871-1088; 61314-224; 61314-227; 0378-0221; 67877-229; 72485-602; 73152-029; 38779-0366; 51014-7510; 52423-0913; 17478-288; 17478-289; 24208-816; 42571-398; 0187-1498; 82260-045; 17337-0543; 24208-004; 60505-1005; 60758-802; 82260-818; 55545-0440; 64330-014; 45865-121; 0378-0715; 73152-031; 70447-0002; 24208-819; 50090-0558; 0378-0055; 64980-513; 69918-601; 69918-602; 70756-657; 82260-813; 24208-496; 50090-5769; 50742-288; 73152-030; 46014-1059; 24208-814; 0187-1496; 70756-655; 82260-496; 24208-499; 24208-818
UNII P8Y54F701R
Synonyms Timolol | Timolol Maleate | Timolol Maleate, (1:1) Salt | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol | 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)- | Timoptic | Timoptol | Timacar | Timolol Hemihydrate | Blocadren | L-714,465 | L 714,465 | L714,465 | MK-950 | MK 950 | MK950 | Optimol
Chemical Information
Molecular Formula C17H28N4O7S
CAS Registry Number 60469-65-0
SMILES CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Atrioventricular block02.03.01.002--Not Available
Blood potassium13.11.01.032--Not Available
Blood triglycerides13.12.03.004--Not Available
Blood urea increased13.13.01.006--Not Available
Blood uric acid13.02.04.003--Not Available
Bradycardia02.03.02.002--Not Available
Bronchial obstruction22.03.01.013--
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Catatonia19.11.01.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain02.02.02.011; 22.12.02.003; 08.01.08.002--Not Available
Colitis ischaemic24.04.08.012; 07.08.01.004--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Cough22.02.03.001--
Depressed level of consciousness17.02.04.002--
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
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