Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tirofiban
Drug ID BADD_D02228
Description Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Indications and Usage For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.
Marketing Status approved
ATC Code B01AC17
DrugBank ID DB00775
KEGG ID D08607
MeSH ID D000077466
PubChem ID 60947
TTD Drug ID D0BN9X
NDC Product Code 68083-145; 25208-001; 25208-002; 55150-430; 55150-429; 25208-901; 25208-902
UNII GGX234SI5H
Synonyms Tirofiban | N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine | Aggrastat | Agrastat | MK 383 | MK-383 | L 700462 | L-700462 | L-700,462 | L 700,462 | L700,462 | Tirofiban Hydrochloride | Tirofiban Hydrochloride Monohydrate
Chemical Information
Molecular Formula C22H36N2O5S
CAS Registry Number 144494-65-5
SMILES CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intracardiac thrombus02.11.01.017; 24.01.05.0030.000082%Not Available
Coronary artery dissection12.02.01.035; 24.02.02.001; 02.02.01.004--Not Available
Catheter site haemorrhage12.07.02.002; 08.02.02.002; 24.07.01.0030.000082%Not Available
Haemorrhage24.07.01.0020.005971%Not Available
Embolism24.01.01.0090.000123%
Infarction24.04.02.0170.001933%Not Available
Ischaemic stroke24.04.06.010; 17.08.01.0180.000164%Not Available
Disease recurrence08.01.03.0500.000082%Not Available
Heparin-induced thrombocytopenia10.02.01.007; 01.08.01.004; 24.01.01.0200.000082%Not Available
Vascular stent thrombosis24.01.01.044; 08.07.05.0020.000164%Not Available
Intracranial haematoma24.07.04.027; 17.08.01.0510.000329%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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