Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tirofiban hydrochloride
Drug ID BADD_D02229
Description Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation.
Indications and Usage For treatment, in combination with heparin, of acute coronary syndrome, including patients who are to be managed medically and those undergoing PTCA or atherectomy.
Marketing Status approved
ATC Code B01AC17
DrugBank ID DB00775
KEGG ID D01029
MeSH ID D000077466
PubChem ID 60946
TTD Drug ID D0BN9X
NDC Product Code 46439-8750; 13612-0009; 14537-102; 82169-025
UNII 6H925F8O5J
Synonyms Tirofiban | N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine | Aggrastat | Agrastat | MK 383 | MK-383 | L 700462 | L-700462 | L-700,462 | L 700,462 | L700,462 | Tirofiban Hydrochloride | Tirofiban Hydrochloride Monohydrate
Chemical Information
Molecular Formula C22H39ClN2O6S
CAS Registry Number 150915-40-5
SMILES CCCCS(=O)(=O)NC(CC1=CC=C(C=C1)OCCCCC2CCNCC2)C(=O)O.O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pulmonary alveolar haemorrhage24.07.01.015; 22.01.02.005--Not Available
Pyrexia08.05.02.003--
Retroperitoneal haemorrhage12.01.17.018; 24.07.01.017; 07.07.02.002--
Swelling08.01.03.015--Not Available
Thrombocytopenia01.08.01.002--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Coronary artery dissection02.02.01.004; 12.02.01.035; 24.02.02.001--Not Available
Spinal epidural haematoma24.07.04.020; 17.08.01.038; 12.01.13.006--Not Available
Haemorrhage24.07.01.002--Not Available
Urine output increased13.13.03.002--Not Available
Occult blood positive13.05.02.001--Not Available
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