| Drug Name |
Tizanidine hydrochloride |
| Drug ID |
BADD_D02231 |
| Description |
Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury [T574]. It may also be caused by musculoskeletal injury [A177583]. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition.
Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons promoting muscle spasm [FDA label]. |
| Indications and Usage |
Tizanidine is indicated for the relief of muscle spasticity, which can interfere with daily activities. The general recommendation is to reserve tizanidine use for periods of time when there is a particular need for relief, as it has a short duration of action [FDA label, F4471]. |
| Marketing Status |
approved; investigational |
| ATC Code |
M03BX02 |
| DrugBank ID |
DB00697
|
| KEGG ID |
D00776
|
| MeSH ID |
C023754
|
| PubChem ID |
114869
|
| TTD Drug ID |
D01MDT
|
| NDC Product Code |
75834-209; 51927-0020; 42291-811; 46708-492; 50742-225; 42291-810; 59651-314; 59651-315; 62332-493; 63629-2466; 72241-043; 46708-493; 59651-316; 60505-2650; 61919-196; 63629-2494; 71209-064; 71209-066; 63629-2467; 63629-5139; 70771-1069; 71209-065; 0591-2789; 72888-002; 55700-865; 60505-2648; 62332-492; 0591-2788; 71335-9743; 71610-114; 75834-208; 55700-999; 60505-2649; 70515-606; 70710-1112; 70771-1067; 72241-041; 49999-347; 70710-1113; 70771-1068; 71335-1698; 38779-2351; 65015-777; 42291-812; 46708-491; 50742-226; 62332-491; 70515-604; 71335-0317; 0591-2790; 75834-207; 66022-0202; 45865-954; 68788-8478; 70515-602; 70710-1111; 72888-003; 53747-003; 50742-224; 70515-594; 72241-042; 72888-001; 55111-020; 63278-0489 |
| UNII |
B53E3NMY5C
|
| Synonyms |
tizanidine | 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole | Zanaflex | tizanidine hydrochloride | tizanidine monohydrochloride | DS 103-282 | Sirdalud |
