| Drug Name |
Trazodone hydrochloride |
| Drug ID |
BADD_D02267 |
| Description |
Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants.[A181180] It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the treatment of depression.[T646] A unique feature of this drug is that it does not promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and SNRI therapy.[T646] Trazodone acts on various receptors, including certain histamine, serotonin, and adrenergic receptors, distinguishing it from other antidepressants that cover a narrow range of neurotransmitters.[T646] It was initially granted FDA approval in 1981.[L3484] |
| Indications and Usage |
Trazodone is indicated for the treatment of major depressive disorder (MDD).[L3484] It has been used off-label for adjunct therapy in alcohol dependence, and off-label to treat anxiety and insomnia.[L3484] It may also be used off-label to treat symptoms of dementia, Alzheimer’s disease, schizophrenia, eating disorders, and fibromyalgia due to its effects on various neurotransmitter receptors.[A31634] |
| Marketing Status |
approved; investigational |
| ATC Code |
N06AX05 |
| DrugBank ID |
DB00656
|
| KEGG ID |
D00820
|
| MeSH ID |
D014196
|
| PubChem ID |
62935
|
| TTD Drug ID |
D00USF
|
| NDC Product Code |
16729-299; 53002-1105; 60505-2654; 60687-454; 61919-613; 68071-2822; 69584-884; 70518-2793; 70518-2973; 0555-0711; 70934-818; 71610-514; 82982-047; 0904-6869; 59651-704; 59651-706; 13668-331; 16729-302; 42291-869; 50111-450; 50111-560; 53002-4105; 55154-8087; 57664-053; 60760-806; 63187-680; 68071-2996; 68788-7137; 70518-3403; 71205-630; 71335-1575; 71610-530; 0615-8386; 13668-330; 13668-333; 51655-662; 53489-511; 60505-2653; 68071-4410; 68788-7118; 70771-1129; 70771-1131; 71205-505; 71335-1630; 55700-739; 68382-806; 69584-885; 70771-1130; 71335-0742; 71335-2084; 72789-079; 50090-4825; 50090-6121; 53002-1132; 55700-810; 57664-014; 60505-2655; 60687-443; 61919-386; 61919-473; 61919-631; 63187-133; 67296-2049; 68071-5187; 68382-805; 70518-3426; 70518-3756; 71205-551; 71205-815; 71335-0705; 71335-1483; 71610-529; 0615-8371; 80425-0298; 51927-0215; 45865-431; 51655-366; 51655-986; 55700-844; 60687-432; 67296-1438; 68071-2959; 68382-808; 70518-1204; 70518-2929; 70518-3479; 70771-1128; 70934-817; 71205-568; 71335-0730; 80425-0302; 0904-7212; 13107-081; 13107-082; 16729-301; 50090-2373; 53002-3132; 55154-8085; 70518-2180; 0615-8339; 72789-168; 82053-002; 13107-080; 13668-332; 16729-300; 42291-868; 50111-561; 51655-658; 63187-377; 71610-511; 38779-0559; 59651-707; 62207-019; 13107-079; 53002-2132; 53489-510; 55700-957; 60505-2659; 68382-807; 70518-3082; 71610-525; 72789-154; 80425-0326; 0904-6868; 24823-911; 46014-1118; 59651-705; 50090-4283; 50090-5218; 55700-855; 63187-086; 68788-7166; 70518-3290; 71205-574; 71610-513; 71610-537; 58159-072; 65015-602; 65085-0014; 42291-829; 43353-973; 43353-974; 50090-2374; 50268-776; 53489-517; 55700-921; 57664-026 |
| UNII |
6E8ZO8LRNM
|
| Synonyms |
Trazodone | Tradozone | AF-1161 | AF 1161 | AF1161 | Deprax | Desyrel | Gen-Trazodone | Gen Trazodone | Molipaxin | Novo-Trazodone | Novo Trazodone | Trittico | PMS-Trazodone | PMS Trazodone | Ratio-Trazodone | Ratio Trazodone | RatioTrazodone | Thombran | Trazodon Hexal | Trazodon-Neuraxpharm | Trazodon Neuraxpharm | TrazodonNeuraxpharm | Trazodone Hydrochloride | Trazon | Apo-Trazodone | Apo Trazodone | Nu-Trazodone | Nu Trazodone |
