| Pharmaceutical Information |
| Drug Name |
Trihexyphenidyl |
| Drug ID |
BADD_D02284 |
| Description |
Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.[A229103] Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects.[L31843] It has largely been replaced by drugs such as [levodopa].[L31843]
Trihexyphenidyl was granted FDA approval on 13 May 1949.[L31768] |
| Indications and Usage |
Tihexyphenidyl is indicated as an adjunct in the treatment of parkinsonism, an adjuvant in the treatment of parkinsonism with levodopa, and in the control of extrapyramidal disorders caused by central nervous system drugs.[L31773,L31778] |
| Marketing Status |
approved |
| ATC Code |
N04AA01 |
| DrugBank ID |
DB00376
|
| KEGG ID |
D08638
|
| MeSH ID |
D014282
|
| PubChem ID |
5572
|
| TTD Drug ID |
D09GFL
|
| NDC Product Code |
63850-6535 |
| UNII |
6RC5V8B7PO
|
| Synonyms |
Trihexyphenidyl | Benzhexol | Artane | Cyclodol | Hipokinon | Trihexyphenidyl Hydrochloride Elixir | Parkopan | Trihexane | Trihexidyl Hydrochloride | Trihexyphenidyl Hydrochloride | Apo-Trihex | Apo Trihex | ApoTrihex | Parkinane |
|
| Chemical Information |
| Molecular Formula |
C20H31NO |
| CAS Registry Number |
144-11-6 |
| SMILES |
C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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