Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Trimethobenzamide hydrochloride
Drug ID BADD_D02289
Description Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against emesis induced by intragastric copper sulfate.
Indications and Usage For the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis.
Marketing Status approved; investigational
ATC Code R06AA10
DrugBank ID DB00662
KEGG ID D02733
MeSH ID C100146
PubChem ID 68385
TTD Drug ID D0A8FB
NDC Product Code 71335-0800; 52584-119; 42023-119; 14593-884; 43386-660; 0404-9964; 63629-3685; 53489-376
UNII WDQ5P1SX7Q
Synonyms trimethobenzamide | trimethobenzamide monohydrochloride | Tebamide | Ticon | Tigan | T-Gen
Chemical Information
Molecular Formula C21H29ClN2O5
CAS Registry Number 554-92-7
SMILES CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C(=C2)OC)OC)OC.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Coma17.02.09.001--Not Available
Depression19.15.01.001--
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness17.02.05.003; 02.11.04.006; 24.06.02.007--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Muscle spasms15.05.03.004--
Opisthotonus17.01.03.005--Not Available
Parkinsonism17.01.05.003--Not Available
Seizure17.12.03.001--
Somnolence19.02.05.003; 17.02.04.006--
Vision blurred17.17.01.010; 06.02.06.007--
Blood disorder01.05.01.004--Not Available
The 1th Page    1    Total 1 Pages