Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Troglitazone
Drug ID BADD_D02301
Description Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone].
Indications and Usage For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.
Marketing Status approved; investigational; withdrawn
ATC Code A10BG01
DrugBank ID DB00197
KEGG ID D00395
MeSH ID D000077288
PubChem ID 5591
TTD Drug ID D06XZW
NDC Product Code Not Available
UNII I66ZZ0ZN0E
Synonyms Troglitazone | 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione) - T | CS 045 | CS-045 | CS045 | Rezulin | Prelay
Chemical Information
Molecular Formula C24H27NO5S
CAS Registry Number 97322-87-7
SMILES CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alanine aminotransferase increased13.03.04.005--
Anaemia01.03.02.001--
Asthenia08.01.01.001--Not Available
Body temperature increased13.15.01.001--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Discomfort08.01.08.003--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal pain07.01.05.005--
Hepatic function abnormal09.01.02.001--Not Available
Hepatitis09.01.07.004--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Laboratory test abnormal13.18.01.001--Not Available
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Nausea07.01.07.001--
Oedema08.01.07.006; 14.05.06.010--Not Available
Shock24.06.02.002--Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Volume blood increased13.11.02.001--Not Available
Vomiting07.01.07.003--
Weight increased13.15.01.006--
Idiosyncratic drug reaction08.06.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Ill-defined disorder08.01.03.049--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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