Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tromethamine
Drug ID BADD_D02302
Description An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)
Indications and Usage For the prevention and correction of metabolic acidosis.
Marketing Status approved
ATC Code B05XX02; B05BB03
DrugBank ID DB03754
KEGG ID D00396
MeSH ID D014325
PubChem ID 6503
TTD Drug ID D03ZFN
NDC Product Code 64173-101; 64173-204; 42533-114; 0409-1593
UNII 023C2WHX2V
Synonyms Tromethamine | Tris Buffer | Tri(hydroxymethyl)aminomethane | Trometamol | Tris(hydroxymethyl)aminomethane | Trisamine | Trizma | Tris-Magnesium(II)-Potassium Chloride Buffer | Tris-Mg(II)-KCl Buffer
Chemical Information
Molecular Formula C4H11NO3
CAS Registry Number 77-86-1
SMILES C(C(CO)(CO)N)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood glucose decreased13.02.02.001--Not Available
Body temperature increased13.15.01.001--Not Available
Extravasation08.01.03.008--Not Available
Hepatic necrosis09.01.07.002--
Hypervolaemia02.05.04.019; 14.05.06.003--Not Available
Hypoventilation22.02.01.007--Not Available
Hypoxia22.02.02.003--
Infection11.01.08.002--Not Available
Injection site infection11.01.08.005; 08.02.03.019; 12.07.03.008--Not Available
Peripheral vascular disorder24.03.01.003--Not Available
Phlebitis24.12.03.004; 12.02.01.002--
Pyrexia08.05.02.003--
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Vasospasm24.04.02.002--Not Available
Venous thrombosis24.01.01.008--Not Available
Pulmonary function test decreased13.19.01.001--Not Available
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