Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valrubicin
Drug ID BADD_D02330
Description Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the [doxorubicin], which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
Indications and Usage For the treatment of cancer of the bladder.
Marketing Status approved
ATC Code L01DB09
DrugBank ID DB00385
KEGG ID D02697
MeSH ID C016163
PubChem ID 454216
TTD Drug ID D07IPB
NDC Product Code 67979-001; 77391-005
UNII 2C6NUM6878
Synonyms valrubicin | N-trifluoroacetyladriamycin 14-valerate | Valtaxin | Valstar | AD 32 | AD-32 | NSC-246131
Chemical Information
Molecular Formula C34H36F3NO13
CAS Registry Number 56124-62-0
SMILES CCCCC(=O)OCC(=O)C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4OC)O)OC5CC(C(C(O 5)C)O)NC(=O)C(F)(F)F)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.000761%
Ageusia17.02.07.001; 07.14.03.003--Not Available
Anaemia01.03.02.001--
Asthenia08.01.01.0010.000246%Not Available
Back pain15.03.04.005--
Bladder irritation20.02.02.0200.000381%Not Available
Bladder pain20.02.02.001--Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.0290.000381%Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Cystitis11.01.14.001; 20.03.02.002--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.11.04.006--
Drug ineffective08.06.01.0060.000627%Not Available
Dysuria20.02.02.0020.000246%
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.0090.000951%Not Available
Flatulence07.01.04.002--
Frequent bowel movements07.02.04.0020.000381%Not Available
Gastrointestinal pain07.01.05.005--
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
Headache17.14.01.001--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Instillation site pain12.07.01.008; 08.02.01.0080.000112%Not Available
Irritability19.04.02.013; 08.01.03.011--
Local reaction08.01.03.012--Not Available
Malaise08.01.01.003--
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