Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valrubicin
Drug ID BADD_D02330
Description Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. It is a semisynthetic analog of the [doxorubicin], which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.
Indications and Usage For the treatment of cancer of the bladder.
Marketing Status approved
ATC Code L01DB09
DrugBank ID DB00385
KEGG ID D02697
MeSH ID C016163
PubChem ID 454216
TTD Drug ID D07IPB
NDC Product Code 67979-001; 77391-005
UNII 2C6NUM6878
Synonyms valrubicin | N-trifluoroacetyladriamycin 14-valerate | Valtaxin | Valstar | AD 32 | AD-32 | NSC-246131
Chemical Information
Molecular Formula C34H36F3NO13
CAS Registry Number 56124-62-0
SMILES CCCCC(=O)OCC(=O)C1(CC(C2=C(C1)C(=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4OC)O)OC5CC(C(C(O 5)C)O)NC(=O)C(F)(F)F)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Micturition urgency20.02.02.006--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nocturia20.02.03.001--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Pain08.01.08.0040.000571%
Pelvic pain21.10.01.001; 07.01.06.012; 20.02.03.007--
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Pollakiuria20.02.02.007--
Proctalgia07.03.02.001--
Pruritus23.03.12.001--
Pyrexia08.05.02.0030.000437%
Rash23.03.13.0010.000571%Not Available
Skin irritation23.03.04.009--Not Available
Urethral pain20.02.02.014--Not Available
Urethritis20.07.02.001; 11.01.14.008--
Urge incontinence20.02.02.0080.002149%Not Available
Urinary incontinence20.02.02.010; 17.05.01.0080.000627%
Urinary retention20.02.02.011--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urine flow decreased20.02.02.012--Not Available
Vomiting07.01.07.003--
Bladder spasm20.02.02.0130.001142%
Musculoskeletal discomfort15.03.04.001--Not Available
Thermal burn23.03.11.042; 12.05.04.001--
Rectal tenesmus15.05.03.011; 07.03.03.001--Not Available
Vasodilation procedure25.03.01.001--Not Available
Ill-defined disorder08.01.03.0490.000571%Not Available
Disease progression08.01.03.0380.000112%
Drug intolerance08.06.01.0130.000571%Not Available
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