Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vernakalant hydrochloride
Drug ID BADD_D02351
Description Vernakalant was developed by Cardiome Pharma as as an antiarrhythmic drug intended for rapid conversion of atrial fibrillation to sinus rhythm. It acts as an atypical class III antiarrhythmic drug that potentiates its effect in higher heart rates. Intravenous formulation was approved in Europe in September 2010 as Brinavess and in Canada in April 2017. It is an investigational drug under regulatory review by FDA.
Indications and Usage Indicated for the rapid conversion of recent onset of atrial fibrillation to sinus rhythm in adults for non-surgery patients that lasts for less than 7 days of duration and post-cardiac surgery patients with atrial fibrillation lasting less than 3 days of duration.
Marketing Status approved; investigational
ATC Code C01BG11
DrugBank ID DB06217
KEGG ID D06665
MeSH ID C524581
PubChem ID 9930048
TTD Drug ID D00OTL
NDC Product Code Not Available
UNII 7G4J1ZD9UQ
Synonyms vernakalant | RSD 1235 | RSD1235 | RSD-1235
Chemical Information
Molecular Formula C20H32ClNO4
CAS Registry Number 748810-28-8
SMILES COC1=C(C=C(C=C1)CCOC2CCCCC2N3CCC(C3)O)OC.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Atrial flutter02.03.03.003--
Atrioventricular block complete02.03.01.003--
Atrioventricular block first degree02.03.01.004--
Bradycardia02.03.02.002--Not Available
Bundle branch block left02.03.01.007--Not Available
Bundle branch block right02.03.01.011--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.009--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.12.02.003--Not Available
Choking sensation22.12.03.004; 19.01.02.002--Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Cough22.02.03.001--
Defaecation urgency07.02.04.001--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Electrocardiogram QRS complex13.14.05.034--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Eye disorder06.08.03.001--Not Available
Eye irritation06.04.05.003--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.009--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
The 1th Page    1 2 3    Next   Last    Total 3 Pages