Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loperamide
Drug ID BADD_D02428
Description One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Indications and Usage For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Marketing Status approved
ATC Code A07DA03
DrugBank ID DB00836
KEGG ID D08144
MeSH ID D008139
PubChem ID 3955
TTD Drug ID D0CS2F
NDC Product Code Not Available
UNII 6X9OC3H4II
Synonyms Loperamide | R-18553 | R 18553 | R18553 | Imodium | Loperamide Hydrochloride | Hydrochloride, Loperamide | Loperamide Monohydrochloride | Monohydrochloride, Loperamide
Chemical Information
Molecular Formula C29H33ClN2O2
CAS Registry Number 53179-11-6
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal failure20.01.03.0050.000338%Not Available
Respiratory arrest22.02.01.0090.000676%Not Available
Respiratory depression22.02.01.010; 17.02.05.0470.001352%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000507%
Restlessness19.11.02.002; 17.02.05.0210.000744%
Rhabdomyolysis15.05.05.0020.001014%
Rhinorrhoea22.12.03.021--
Seizure17.12.03.0010.001690%
Shock24.06.02.0020.000338%Not Available
Sinus bradycardia02.03.03.0090.001521%
Skin exfoliation23.03.07.003--Not Available
Sleep disorder19.02.04.001--Not Available
Small intestinal obstruction07.13.06.001--
Somnolence19.02.05.003; 17.02.04.0060.001352%
Stress19.06.02.004--Not Available
Swelling08.01.03.0150.000338%Not Available
Syncope02.11.04.015; 17.02.04.008; 24.06.02.0120.004225%
Tachycardia02.03.02.0070.001690%Not Available
Torsade de pointes02.03.04.0050.008113%Not Available
Unresponsive to stimuli17.02.05.0310.000507%Not Available
Urinary incontinence20.02.02.010; 17.05.01.0080.000338%
Ventricular arrhythmia02.03.04.0060.001183%
Ventricular fibrillation02.03.04.0080.002197%
Ventricular tachycardia02.03.04.0100.009296%
Visual impairment06.02.10.013--Not Available
Vomiting07.01.07.0030.002265%
Withdrawal syndrome19.07.06.023; 08.06.02.0120.001352%Not Available
Mental status changes19.07.01.0010.000507%Not Available
Cardiotoxicity02.11.01.009; 12.03.01.0070.002535%Not Available
Peripheral swelling08.01.03.053; 02.05.04.015--Not Available
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